Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 5/20 | 0.64 |
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.48 |
| ▸ | MCOLN3 | Q8TDD5 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.40 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.40 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.40 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.40 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.40 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6973981 | 0.84 | HTR6 (0.59) | HTR6ALDH1A1KMT2AMEN1LMNA | |
| SCHEMBL6978521 | 0.84 | HTR6 (0.61) | HTR6ALDH1A1TDP1DRD2HTR2C | |
| SCHEMBL6980473 | 0.84 | HTR6 (0.58) | HTR6MAPTALDH1A1TDP1MCOLN3 | |
| SCHEMBL6980766 | 0.82 | HTR6 (0.64) | HTR6ALDH1A1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL6972659 | 0.82 | HTR6 (0.53) | HTR6DRD2HTR2CDRD3 | |
| SCHEMBL6975641 | 0.81 | HTR6 (0.62) | HTR6MAPTALDH1A1KMT2AMEN1 | |
| SCHEMBL6979282 | 0.78 | HTR6 (0.60) | HTR6MAPTALDH1A1KMT2AMEN1 | |
| SCHEMBL6977914 | 0.78 | HTR6 (0.59) | HTR6MAPTALDH1A1TDP1KMT2A | |
| SCHEMBL7200160 | 0.78 | HTR6 (1.00) | HTR6L3MBTL1DRD2HTR2CDRD3 | |
| SCHEMBL6974064 | 0.77 | HTR6 (0.55) | HTR6MAPTALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0946539-B1 | SULPHONAMIDE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS MEDICAMENTS | SMITHKLINE BEECHAM PLC (GB) | 2003-08-13 | — | — | EP | claimed |
| US-6599904-B2 | 5-HT6 receptor antagonists are believed to be of potential use in the treatment of certain CNS disorders; cognitive memory enhancement | SMITHKLINE BEECHAM P.L.C. (GB) | 2003-07-29 | — | — | US | disclosed |