Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | GBA1 | P04062 | 2/20 | 0.43 |
| ▸ | LTA4H | P09960 | 2/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27892178 | 0.81 | POLB (0.62) | POLBGBA1LTA4HSLC6A2SLC6A4 | |
| SCHEMBL11470451 | 0.80 | POLB (0.60) | POLBGBA1LTA4HSLC6A2SLC6A4 | |
| SCHEMBL11285029 | 0.78 | POLB (0.57) | POLBGBA1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL7389180 | 0.78 | POLB (0.57) | POLBGBA1LTA4H | |
| SCHEMBL7389183 | 0.78 | POLB (0.57) | POLBGBA1LTA4H | |
| SCHEMBL7389177 | 0.78 | POLB (0.57) | POLBGBA1LTA4H | |
| SCHEMBL6972853 | 0.76 | POLB (0.55) | POLBGBA1LTA4H | |
| SCHEMBL28954933 | 0.76 | POLB (0.52) | POLBGBA1ADRA2AADRA2BADRA2C | |
| SCHEMBL2707343 | 0.75 | POLB (1.00) | POLBGBA1LTA4H | |
| SCHEMBL8872248 | 0.75 | POLB (1.00) | POLBGBA1LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0821674-B1 | CYCLIC AMIDINO AGENTS USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | SEARLE & CO (US) | 2003-08-06 | — | — | EP | claimed |