Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | LTA4H | P09960 | 2/20 | 0.42 |
| ▸ | GBA1 | P04062 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11470451 | 0.80 | POLB (0.60) | POLBLTA4HGBA1 | |
| SCHEMBL27892178 | 0.78 | POLB (0.62) | POLBLTA4HGBA1 | |
| SCHEMBL6980965 | 0.76 | POLB (0.60) | POLBLTA4HGBA1 | |
| SCHEMBL23459335 | 0.76 | POLB (0.55) | POLBLTA4H | |
| SCHEMBL23459334 | 0.76 | POLB (0.55) | POLBLTA4H | |
| SCHEMBL25698181 | 0.74 | ALDH1A1 (0.46) | POLB | |
| SCHEMBL7389183 | 0.74 | POLB (0.57) | POLBLTA4HGBA1 | |
| SCHEMBL7389177 | 0.74 | POLB (0.57) | POLBLTA4HGBA1 | |
| SCHEMBL7389180 | 0.74 | POLB (0.57) | POLBLTA4HGBA1 | |
| SCHEMBL11285029 | 0.74 | POLB (0.57) | POLBGBA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0821674-B1 | CYCLIC AMIDINO AGENTS USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | SEARLE & CO (US) | 2003-08-06 | — | — | EP | disclosed |
| US-6011028-A | Cyclic amidino agents useful as nitric oxide synthase inhibitors | G.D. SEARLE & CO. (US) | 2000-01-04 | — | — | US | disclosed |
| EP-0821674-A1 | CYCLIC AMIDINO AGENTS USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | G.D. SEARLE & CO. (US) | 1998-02-04 | — | — | EP | disclosed |
| WO-1996033175-A1 | CYCLIC AMIDINO AGENTS USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | G.D. SEARLE & CO. (US) | 1996-10-24 | — | — | WO | disclosed |