Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 6/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 2/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.34 |
| ▸ | HTR2B | P41595 | 2/20 | 0.34 |
| ▸ | HTR6 | P50406 | 2/20 | 0.34 |
| ▸ | MPO | P05164 | 1/20 | 0.33 |
| ▸ | CDK1 | P06493 | 1/20 | 0.33 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.33 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | MAOA | P21397 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6986723 | 0.99 | CHRM1 (0.37) | CHRM1SMN1; SMN2HTR2CSLC6A4HTR2B | |
| SCHEMBL6984398 | 0.88 | ALDH1A1 (0.42) | CHRM1HTR2CSLC6A4HTR2BALDH1A1 | |
| Hydrochloric Acid SCHEMBL6987919 | 0.87 | ALDH1A1 (0.41) | CHRM1HTR2CSLC6A4HTR2BALDH1A1 | |
| Hydrochloric Acid SCHEMBL6987410 | 0.85 | CHRM1 (0.37) | CHRM1HTR2CSLC6A4HTR2B | |
| SCHEMBL6982712 | 0.84 | CHRM1 (0.38) | CHRM1SMN1; SMN2 | |
| SCHEMBL6981312 | 0.78 | CHRM1 (0.43) | CHRM1 | |
| SCHEMBL6983586 | 0.77 | CHRM1 (0.36) | CHRM1 | |
| SCHEMBL9170970 | 0.60 | DRD3 (0.41) | CHRM1HTR2CSLC6A4HTR2BHTR6 | |
| SCHEMBL9170960 | 0.60 | DRD3 (0.41) | CHRM1HTR2CSLC6A4HTR2BHTR6 | |
| SCHEMBL18986887 | 0.54 | BCHE (0.48) | HTR2CSLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1189902-B1 | 7-OXO-2-AZABICYCLO[2.2.1]HEPTANES AS SELECTIVE MUSCARINIC RECEPTOR ANTAGONIST | LILLY CO ELI (US) | 2003-08-27 | — | — | EP | claimed |
| US-6559171-B1 | Muscarinic receptor modulators 7-oxo-2-azabicyclo(2.2.1)heptanes of formula (I) which are useful for the treatment of various diseases and conditions, for example, Alzheimer's disease, glaucoma, psychosis, | ELI LILLY AND COMPANY | 2003-05-06 | — | — | US | claimed |