Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CTBP2 | P56545 | 1/20 | 0.39 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11406469 | 0.77 | MEN1 (0.62) | MEN1KMT2AMAPTALDH1A1KDM4E | |
| SCHEMBL6981876 | 0.75 | IDO1 (0.40) | MEN1KMT2AMAPTALDH1A1KDM4E | |
| SCHEMBL10901107 | 0.69 | — | — | |
| SCHEMBL10901100 | 0.69 | — | — | |
| SCHEMBL3860356 | 0.69 | IDO1 (0.45) | MEN1KMT2AMAPTALDH1A1CTBP2 | |
| SCHEMBL5898755 | 0.69 | IDO1 (0.45) | MEN1KMT2AMAPTALDH1A1CTBP2 | |
| SCHEMBL11199924 | 0.69 | TDP1 (0.46) | MEN1KMT2AMAPTALDH1A1PTGDR | |
| SCHEMBL11199920 | 0.69 | TDP1 (0.46) | MEN1KMT2AMAPTALDH1A1PTGDR | |
| SCHEMBL6983491 | 0.69 | CYP2C19 (0.42) | MEN1KMT2AALDH1A1KDM4EPOLB | |
| SCHEMBL1759771 | 0.68 | NR4A2 (0.50) | ALDH1A1TDP1CYP1A2CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0991643-B1 | NOVEL AMINOOXYAMIDE TRICYCLIC INHIBITORS OF FARNESYLPROTEIN TRANSFERASE | SCHERING CORP (US) | 2003-04-02 | — | — | EP | disclosed |
| EP-0991643-A1 | NOVEL AMINOOXYAMIDE TRICYCLIC INHIBITORS OF FARNESYLPROTEIN TRANSFERASE | SCHERING CORPORATION (US) | 2000-04-12 | — | — | EP | disclosed |
| US-5945430-A | BENZO(5,6)CYCLOHEPTAPYRIDINE COMPOUNDS THAT INHIBIT RAS FUNCTION, USE FOR TREATING TUMOR CELLS EXPRESSING AN ACTIVATED RAS ONCOGENE IN MAMMALS | SCHERING CORPORATION (US) | 1999-08-31 | — | — | US | disclosed |
| WO-1998057965-A1 | NOVEL AMINOOXYAMIDE TRICYCLIC INHIBITORS OF FARNESYLPROTEIN TRANSFERASE | SCHERING CORPORATION (US) | 1998-12-23 | — | — | WO | disclosed |