Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 5/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.38 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.38 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.37 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9558609 | 0.78 | HPGD (0.38) | POLBTDP1HPGDNPC1KMT2A | |
| SCHEMBL9558559 | 0.78 | HPGD (0.38) | POLBTDP1HPGDNPC1KMT2A | |
| SCHEMBL15347875 | 0.77 | POLB (0.41) | CYP2C19POLBHPGDNPC1KMT2A | |
| SCHEMBL6983487 | 0.77 | POLB (0.41) | CYP2C19POLBHPGDNPC1KMT2A | |
| SCHEMBL9744645 | 0.75 | ALDH1A1 (0.38) | POLBHPGDNPC1KMT2AMEN1 | |
| SCHEMBL7878676 | 0.74 | TAAR1 (0.38) | CYP2C19POLBTDP1NPC1ALDH1A1 | |
| SCHEMBL9557896 | 0.73 | ALDH1A1 (0.45) | CYP2C19POLBTDP1HPGDNPC1 | |
| SCHEMBL14938536 | 0.72 | ALDH1A1 (0.48) | CYP2C19POLBHPGDNPC1KMT2A | |
| SCHEMBL9038549 | 0.71 | — | — | |
| SCHEMBL9038543 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0991643-B1 | NOVEL AMINOOXYAMIDE TRICYCLIC INHIBITORS OF FARNESYLPROTEIN TRANSFERASE | SCHERING CORP (US) | 2003-04-02 | — | — | EP | disclosed |
| EP-0991643-A1 | NOVEL AMINOOXYAMIDE TRICYCLIC INHIBITORS OF FARNESYLPROTEIN TRANSFERASE | SCHERING CORPORATION (US) | 2000-04-12 | — | — | EP | disclosed |
| US-5945430-A | BENZO(5,6)CYCLOHEPTAPYRIDINE COMPOUNDS THAT INHIBIT RAS FUNCTION, USE FOR TREATING TUMOR CELLS EXPRESSING AN ACTIVATED RAS ONCOGENE IN MAMMALS | SCHERING CORPORATION (US) | 1999-08-31 | — | — | US | disclosed |
| WO-1998057965-A1 | NOVEL AMINOOXYAMIDE TRICYCLIC INHIBITORS OF FARNESYLPROTEIN TRANSFERASE | SCHERING CORPORATION (US) | 1998-12-23 | — | — | WO | disclosed |