Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 14/20 | 0.71 |
| ▸ | SLC6A2 | P23975 | 13/20 | 0.71 |
| ▸ | SLC6A4 | P31645 | 13/20 | 0.71 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6986107 | 0.95 | SLC6A3 (0.64) | SLC6A3SLC6A2SLC6A4HIF1AHSD17B10 | |
| SCHEMBL28747194 | 0.83 | SLC6A2 (0.71) | SLC6A3SLC6A2SLC6A4HIF1AHSD17B10 | |
| SCHEMBL26720835 | 0.83 | SLC6A3 (0.71) | SLC6A3SLC6A2SLC6A4 | |
| SCHEMBL14601979 | 0.83 | SLC6A3 (0.71) | SLC6A3SLC6A2SLC6A4 | |
| SCHEMBL26840808 | 0.83 | SLC6A3 (0.71) | SLC6A3SLC6A2SLC6A4 | |
| SCHEMBL14453326 | 0.83 | SLC6A3 (0.71) | SLC6A3SLC6A2SLC6A4 | |
| SCHEMBL14602065 | 0.83 | SLC6A3 (0.71) | SLC6A3SLC6A2SLC6A4 | |
| SCHEMBL13060552 | 0.83 | SLC6A3 (0.71) | SLC6A3SLC6A2SLC6A4 | |
| SCHEMBL3164269 | 0.81 | HIF1A (0.62) | SLC6A3SLC6A2SLC6A4HIF1AHSD17B10 | |
| SCHEMBL27802908 | 0.80 | SLC6A2 (0.66) | SLC6A3SLC6A2SLC6A4HIF1AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100338036-C | Substituted indolinones with inhibitory effect on kinase and cyclin complexes | BOEHRINGER INGELHEIM PHARMA (DE) | 2007-09-19 | — | — | CN | disclosed |
| EP-1071665-B1 | SUBSTITUTED INDOLINONES HAVING AN INHIBITING EFFECT ON KINASES AND CYCLINE/CDK COMPLEXES | BOEHRINGER INGELHEIM PHARMA (DE) | 2003-10-01 | — | — | EP | disclosed |
| CN-1303374-A | Substituted indolinones, process for their preparation and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM PHARMA (DE) | 2001-07-11 | — | — | CN | disclosed |
| EP-1071665-A1 | SUBSTITUTED INDOLINONES HAVING AN INHIBITING EFFECT ON KINASES AND CYCLINE/CDK COMPLEXES | Boehringer Ingelheim Pharma KG (DE) | 2001-01-31 | — | — | EP | disclosed |
| US-6169106-B1 | ANTITUMOUR AGENTS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2001-01-02 | — | — | US | disclosed |
| WO-1999052869-A1 | SUBSTITUTED INDOLINONES HAVING AN INHIBITING EFFECT ON KINASES AND CYCLINE/CDK COMPLEXES | BOEHRINGER INGELHEIM PHARMA KG (DE) | 1999-10-21 | — | — | WO | disclosed |