Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 5/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.63 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.63 |
| ▸ | ILK | Q13418 | 1/20 | 0.57 |
| ▸ | GLA | P06280 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | SULT1A1 | P50225 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8125517 | 0.89 | APP (0.54) | APPCYP1A2CYP3A4CYP2C19ILK | |
| SCHEMBL229456 | 0.81 | APP (0.68) | APPCYP1A2CYP3A4CYP2C19ILK | |
| SCHEMBL2055237 | 0.80 | APP (0.71) | APPCYP1A2CYP3A4CYP2C19ILK | |
| SCHEMBL12974045 | 0.79 | APP (1.00) | APPCYP1A2CYP3A4CYP2C19GLA | |
| SCHEMBL1977100 | 0.79 | APP (1.00) | APPCYP1A2CYP3A4CYP2C19GLA | |
| SCHEMBL5429982 | 0.78 | APP (0.83) | APPGLAGAANPC1SULT1A1 | |
| SCHEMBL28801433 | 0.78 | APP (0.64) | APPCYP1A2CYP3A4CYP2C19ILK | |
| SCHEMBL29683488 | 0.78 | CYP3A4 (1.00) | APPCYP1A2CYP3A4CYP2C19GAA | |
| SCHEMBL22358 | 0.78 | CYP3A4 (1.00) | APPCYP1A2CYP3A4CYP2C19GAA | |
| SCHEMBL13806286 | 0.77 | APP (0.63) | APPCYP1A2CYP3A4CYP2C19ILK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6150362-A | ADMINISTERING 1,3,5-SUBSTITUTED TRIAZINE COMPOUNDS TO THE PATIENT SUFFERING FROM ANGIOGENIC DISEASES | ABBVIE INC. | 2000-11-21 | — | — | US | claimed |
| EP-1037886-A1 | TRIAZINE ANGIOGENESIS INHIBITORS | Abbott Laboratories (US) | 2000-09-27 | — | — | EP | claimed |
| WO-1999031088-A1 | TRIAZINE ANGIOGENESIS INHIBITORS | ABBOTT LABORATORIES (US) | 1999-06-24 | — | — | WO | claimed |
| EP-1037886-B1 | TRIAZINE ANGIOGENESIS INHIBITORS | ABBOTT LAB (US) | 2003-05-02 | — | — | EP | disclosed |
| US-6288228-B1 | DIAMINOTRIAZINE DERIVATIVES | ABBOTT LABORATORIES | 2001-09-11 | — | — | US | disclosed |
| US-6150362-A | ADMINISTERING 1,3,5-SUBSTITUTED TRIAZINE COMPOUNDS TO THE PATIENT SUFFERING FROM ANGIOGENIC DISEASES | ABBVIE INC. | 2000-11-21 | — | — | US | disclosed |