SCHEMBL6982172

SCHEMBL6982172

COC(=O)C1CCN(C(=O)CO)CC1

nearest known ligand 0.60

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.60
SMN1; SMN2 Q16637 5/20 0.57
L3MBTL1 Q9Y468 1/20 0.57
GAA P10253 1/20 0.57
HTT P42858 1/20 0.56
POLB P06746 1/20 0.53
RAB9A P51151 3/20 0.52
NPC1 O15118 2/20 0.52
TP53 P04637 1/20 0.51
MEN1 O00255 1/20 0.49
KMT2A Q03164 1/20 0.49
KDM4E B2RXH2 1/20 0.47
HPGD P15428 1/20 0.47
HSD17B10 Q99714 1/20 0.47
CREBBP Q92793 1/20 0.46
TSHR P16473 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12846094 0.85 GAA (0.61) ALDH1A1SMN1; SMN2L3MBTL1GAAHTT
SCHEMBL6981751 0.85 ALDH1A1 (0.60) ALDH1A1SMN1; SMN2L3MBTL1GAAHTT
SCHEMBL22481582 0.84 ALDH1A1 (0.59) ALDH1A1SMN1; SMN2L3MBTL1GAAHTT
SCHEMBL14902197 0.84 ALDH1A1 (0.59) ALDH1A1SMN1; SMN2L3MBTL1GAAHTT
SCHEMBL20240120 0.84 ALDH1A1 (0.59) ALDH1A1SMN1; SMN2L3MBTL1GAAHTT
SCHEMBL6983366 0.82 ALDH1A1 (0.68) ALDH1A1SMN1; SMN2TP53MEN1KMT2A
SCHEMBL25039064 0.82 ALDH1A1 (0.57) ALDH1A1SMN1; SMN2L3MBTL1GAAHTT
SCHEMBL16639720 0.81 ALDH1A1 (0.64) ALDH1A1SMN1; SMN2L3MBTL1GAAHTT
SCHEMBL12436034 0.79 ALDH1A1 (0.42) ALDH1A1SMN1; SMN2L3MBTL1GAAPOLB
SCHEMBL3861785 0.79 SMN1; SMN2 (0.62) ALDH1A1SMN1; SMN2L3MBTL1GAAHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0985671-B1 PYRIDOCARBAZOLE DERIVATIVES HAVING cGMP-PDE INHIBITORY EFFECT MOCHIDA PHARM CO LTD (JP) 2003-04-02 EP disclosed
US-6476021-B1 Compounds having cGMP-PDE inhibitory effect MOCHIDA PHARMACEUTICAL CO., LTD. (JP) 2002-11-05 US disclosed
US-6197768-B1 THERAPY, PREVENTION ISCHEMIC HEART DISEASE MOCHIDA PHARMACEUTICAL CO., LTD. (JP) 2001-03-06 US disclosed
EP-1048666-A1 NOVEL COMPOUNDS HAVING cGMP-PDE INHIBITORY EFFECT MOCHIDA PHARMACEUTICAL CO., LTD. (JP) 2000-11-02 EP disclosed
EP-0992240-A1 THERAPEUTIC AGENT FOR ERECTION FAILURE MOCHIDA PHARMACEUTICAL CO., LTD. (JP) 2000-04-12 EP disclosed
EP-0985671-A1 PYRIDOCARBAZOLE DERIVATIVES HAVING cGMP-PDE INHIBITORY EFFECT MOCHIDA PHARMACEUTICAL CO., LTD. (JP) 2000-03-15 EP disclosed
US-6018046-A SELECTIVE ACTION IN INHIBITING CYCLIC GMP-PHOSPHODIESTERASE (CGMP-PDE); PHARMACEUTICALS FOR TREATING DISEASES AGAINST WHICH THE INHIBITORY ACTION IS EFFECTIVE, SUCH AS PULMONARY HYPERTENSION MOCHIDA PHARMACEUTICAL CO., LTD. (JP) 2000-01-25 US disclosed