Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 20/20 | 0.61 |
| ▸ | HTR7 | P34969 | 3/20 | 0.60 |
| ▸ | HTR4 | Q13639 | 3/20 | 0.60 |
| ▸ | HTR1A | P08908 | 2/20 | 0.60 |
| ▸ | DRD2 | P14416 | 2/20 | 0.60 |
| ▸ | HTR1D | P28221 | 2/20 | 0.60 |
| ▸ | HTR1B | P28222 | 2/20 | 0.60 |
| ▸ | HTR2C | P28335 | 2/20 | 0.60 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.60 |
| ▸ | DRD3 | P35462 | 2/20 | 0.60 |
| ▸ | DRD1 | P21728 | 1/20 | 0.60 |
| ▸ | DRD4 | P21917 | 1/20 | 0.60 |
| ▸ | HTR2A | P28223 | 1/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.59 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.59 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6976513 | 0.89 | HTR6 (0.65) | HTR6HTR7HTR4HTR1ADRD2 | |
| SCHEMBL6971169 | 0.85 | HTR6 (0.66) | HTR6HTR7HTR4HTR1ADRD2 | |
| SCHEMBL6983122 | 0.84 | HTR6 (0.65) | HTR6HTR7HTR4HTR1ADRD2 | |
| SCHEMBL6983543 | 0.82 | HTR6 (0.63) | HTR6HTR7HTR4HTR1ADRD2 | |
| SCHEMBL6975332 | 0.79 | HTR6 (0.80) | HTR6HTR7HTR4HTR1ADRD2 | |
| SCHEMBL6980079 | 0.79 | HTR6 (0.80) | HTR6HTR7HTR4HTR1ADRD2 | |
| SCHEMBL6973742 | 0.79 | HTR6 (0.80) | HTR6HTR7HTR4HTR1ADRD2 | |
| SCHEMBL6976495 | 0.78 | HTR6 (0.92) | HTR6HTR7HTR1AHTR2CHTR2B | |
| SCHEMBL15821331 | 0.77 | HTR6 (0.69) | HTR6HTR7HTR4HTR1ADRD2 | |
| SCHEMBL6972576 | 0.77 | HTR6 (0.85) | HTR6HTR7HTR4HTR1ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0946539-B1 | SULPHONAMIDE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS MEDICAMENTS | SMITHKLINE BEECHAM PLC (GB) | 2003-08-13 | — | — | EP | claimed |
| US-6599904-B2 | 5-HT6 receptor antagonists are believed to be of potential use in the treatment of certain CNS disorders; cognitive memory enhancement | SMITHKLINE BEECHAM P.L.C. (GB) | 2003-07-29 | — | — | US | disclosed |