Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 1/20 | 0.41 |
| ▸ | CTSC | P53634 | 1/20 | 0.32 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.32 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.32 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.32 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6987096 | 1.00 | ADAM17 (0.41) | ADAM17CTSCCCNA2CDK2CCNA1 | |
| SCHEMBL6980397 | 0.95 | ADAM17 (0.44) | ADAM17CTSCCCNA2CDK2CCNA1 | |
| SCHEMBL6980398 | 0.95 | ADAM17 (0.44) | ADAM17CTSCCCNA2CDK2CCNA1 | |
| SCHEMBL6987823 | 0.94 | ADAM17 (0.43) | ADAM17CTSCCCNA2CDK2CCNA1 | |
| SCHEMBL6983371 | 0.93 | ADAM17 (0.42) | ADAM17CTSCTGFBR1 | |
| SCHEMBL6982944 | 0.87 | ADAM17 (0.46) | ADAM17CTSCCCNA2CDK2CCNA1 | |
| SCHEMBL6983650 | 0.86 | ADAM17 (0.44) | ADAM17CTSCCCNA2CDK2CCNA1 | |
| SCHEMBL6981370 | 0.86 | ADAM17 (0.44) | ADAM17CTSCCCNA2CDK2CCNA1 | |
| SCHEMBL6988246 | 0.85 | ADAM17 (0.43) | ADAM17CTSCTGFBR1 | |
| SCHEMBL6988681 | 0.85 | ADAM17 (0.43) | ADAM17CTSCTGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1089964-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-10-29 | — | — | EP | disclosed |
| US-6239151-B1 | TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES, OSTEOARTHRITIS, RESPIRATORY DISEASES, TUMORS, CACHEXIA, CARDIOVASCULAR DISEASES, FEVER, HAEMORRHAGE AND SEPSIS, HYDRAZINE DERIVATIVES, | HOFFMANN-LA ROCHE INC. | 2001-05-29 | — | — | US | disclosed |