SCHEMBL6982420

SCHEMBL6982420

Cc1ccc(S(=O)(=O)OC(C)C2CO2)cc1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 2/20 0.39
MEN1 O00255 1/20 0.39
CYP2D6 P10635 3/20 0.38
CYP1A2 P05177 1/20 0.38
GAA P10253 4/20 0.38
LMNA P02545 2/20 0.36
VDR P11473 1/20 0.36
CA12 O43570 1/20 0.36
CA1 P00915 1/20 0.36
CA2 P00918 1/20 0.36
CA3 P07451 1/20 0.36
CA6 P23280 1/20 0.36
CA5A P35218 1/20 0.36
CA7 P43166 1/20 0.36
CA9 Q16790 1/20 0.36
CA5B Q9Y2D0 1/20 0.36
TLR9 Q9NR96 1/20 0.35
ALDH1A1 P00352 3/20 0.34
SMN1; SMN2 Q16637 3/20 0.34
NPSR1 Q6W5P4 2/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6982425 1.00 KMT2A (0.39) KMT2AMEN1CYP2D6CYP1A2GAA
SCHEMBL3454507 0.81 CYP2D6 (0.44) CYP2D6CYP1A2GAALMNAVDR
SCHEMBL16467964 0.80 MEN1 (0.40) KMT2AMEN1CYP2D6CYP1A2GAA
SCHEMBL10832402 0.80 ALDH1A1 (0.51) KMT2AGAALMNACA1CA2
SCHEMBL14780181 0.79 TSHR (0.45) KMT2ACYP2D6CYP1A2GAAALDH1A1
SCHEMBL4578793 0.79 ALDH1A1 (0.49) CYP2D6CYP1A2GAALMNAALDH1A1
SCHEMBL2387009 0.78 MEN1 (0.40) KMT2AMEN1CYP2D6CYP1A2GAA
SCHEMBL2387012 0.78 MEN1 (0.40) KMT2AMEN1CYP2D6CYP1A2GAA
SCHEMBL30500515 0.78 MEN1 (0.40) KMT2AMEN1CYP2D6CYP1A2GAA
SCHEMBL15464976 0.78 HPN (0.41) CYP2D6CYP1A2GAALMNAALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0923575-B1 CYCLIC ETHER COMPOUNDS AS SODIUM CHANNEL MODULATORS TAKEDA CHEMICAL INDUSTRIES LTD (JP) 2003-03-12 EP disclosed
US-6172085-B1 CENTRAL NERVOUS SYSTEM AND PSYCHOLOGICAL DISORDERS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2001-01-09 US disclosed
EP-0923575-A1 CYCLIC ETHER COMPOUNDS AS SODIUM CHANNEL MODULATORS Takeda Chemical Industries, Ltd. (JP) 1999-06-23 EP disclosed
WO-1998008842-A1 CYCLIC ETHER COMPOUNDS AS SODIUM CHANNEL MODULATORS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1998-03-05 WO disclosed