Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 2/20 | 0.58 |
| ▸ | GRIK1 | P39086 | 10/20 | 0.41 |
| ▸ | GRIK2 | Q13002 | 10/20 | 0.41 |
| ▸ | MMP2 | P08253 | 7/20 | 0.38 |
| ▸ | MMP3 | P08254 | 7/20 | 0.38 |
| ▸ | MMP7 | P09237 | 6/20 | 0.38 |
| ▸ | MMP1 | P03956 | 5/20 | 0.37 |
| ▸ | MMP8 | P22894 | 2/20 | 0.37 |
| ▸ | MMP9 | P14780 | 1/20 | 0.37 |
| ▸ | MMP12 | P39900 | 1/20 | 0.37 |
| ▸ | MMP13 | P45452 | 1/20 | 0.37 |
| ▸ | MMP14 | P50281 | 1/20 | 0.37 |
| ▸ | FCER2 | P06734 | 1/20 | 0.35 |
| ▸ | CTSC | P53634 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL6982462 | 1.00 | ADAM17 (0.58) | ADAM17GRIK1GRIK2MMP2MMP3 | |
| Trifluoroacetic Acid SCHEMBL6982454 | 1.00 | ADAM17 (0.58) | ADAM17GRIK1GRIK2MMP2MMP3 | |
| Trifluoroacetic Acid SCHEMBL6985843 | 0.88 | ADAM17 (0.60) | ADAM17GRIK1GRIK2MMP2MMP3 | |
| Trifluoroacetic Acid SCHEMBL7813087 | 0.88 | ADAM17 (0.55) | ADAM17GRIK1GRIK2MMP2MMP3 | |
| SCHEMBL6937771 | 0.87 | ADAM17 (0.69) | ADAM17MMP2MMP3MMP7MMP1 | |
| Trifluoroacetic Acid SCHEMBL6986139 | 0.85 | ADAM17 (0.59) | ADAM17GRIK1GRIK2MMP2MMP3 | |
| SCHEMBL6943851 | 0.85 | ADAM17 (0.67) | ADAM17MMP2MMP3MMP7MMP1 | |
| SCHEMBL6986418 | 0.84 | ADAM17 (0.70) | ADAM17MMP2MMP3MMP7MMP1 | |
| Hydrochloric Acid SCHEMBL6986409 | 0.82 | ADAM17 (0.68) | ADAM17GRIK1GRIK2MMP2MMP3 | |
| Hydrochloric Acid SCHEMBL6984718 | 0.82 | ADAM17 (0.68) | ADAM17GRIK1GRIK2MMP2MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1089964-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-10-29 | — | — | EP | disclosed |
| US-6239151-B1 | TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES, OSTEOARTHRITIS, RESPIRATORY DISEASES, TUMORS, CACHEXIA, CARDIOVASCULAR DISEASES, FEVER, HAEMORRHAGE AND SEPSIS, HYDRAZINE DERIVATIVES, | HOFFMANN-LA ROCHE INC. | 2001-05-29 | — | — | US | disclosed |