Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK4 | O00444 | 4/20 | 0.67 |
| ▸ | AURKA | O14965 | 2/20 | 0.62 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.62 |
| ▸ | KDR | P35968 | 2/20 | 0.56 |
| ▸ | IGF1R | P08069 | 3/20 | 0.56 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.54 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.53 |
| ▸ | JAK2 | O60674 | 2/20 | 0.53 |
| ▸ | JAK3 | P52333 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | PLK1 | P53350 | 1/20 | 0.52 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.52 |
| ▸ | RAF1 | P04049 | 1/20 | 0.51 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.51 |
| ▸ | KIT | P10721 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23887632 | 0.91 | PLK4 (0.74) | PLK4AURKAAURKBIGF1REPHB4 | |
| SCHEMBL6968717 | 0.85 | BRD4 (0.61) | PLK4KDRJAK2JAK3SLC2A1 | |
| SCHEMBL30749035 | 0.84 | MAPK14 (0.52) | PLK4AURKAAURKBIGF1RMEN1 | |
| SCHEMBL16423491 | 0.81 | PLK4 (0.70) | PLK4AURKAAURKBIGF1REPHB4 | |
| SCHEMBL15918396 | 0.80 | PLK4 (0.61) | PLK4AURKAAURKBJAK2JAK3 | |
| SCHEMBL20529569 | 0.79 | PLK4 (0.72) | PLK4AURKAAURKBKDRIGF1R | |
| SCHEMBL28053893 | 0.79 | ALK (0.63) | PLK4AURKAAURKBKDRIGF1R | |
| SCHEMBL28965359 | 0.78 | PLK4 (0.57) | PLK4AURKAAURKBIGF1REPHB4 | |
| SCHEMBL3214863 | 0.78 | PLK4 (0.69) | PLK4AURKAAURKBIGF1REPHB4 | |
| SCHEMBL2061358 | 0.78 | MAPT (0.62) | AURKAAURKBIGF1RMAPK10KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0862560-B1 | SUBSTITUTED 2-ANILINOPYRIMIDINES USEFUL AS PROTEIN KINASE INHIBITORS | CELLTECH THERAPEUTICS LTD (GB) | 2003-04-02 | — | — | EP | disclosed |
| US-6235746-B1 | AUTOIMMUNE DISEASES; ANTIPROLIFERATIVE AGENT | CELLTECH THERAPEUTICS, LIMITED (GB) | 2001-05-22 | — | — | US | disclosed |
| US-5958935-A | Substituted 2-anilinopyrimidines useful as protein kinase inhibitors | CELLTECH THERAPEUTICS LIMITED (GB) | 1999-09-28 | — | — | US | disclosed |
| EP-0862560-A1 | SUBSTITUTED 2-ANILINOPYRIMIDINES USEFUL AS PROTEIN KINASE INHIBITORS | CELLTECH THERAPEUTICS LIMITED (GB) | 1998-09-09 | — | — | EP | disclosed |
| WO-1997019065-A1 | SUBSTITUTED 2-ANILINOPYRIMIDINES USEFUL AS PROTEIN KINASE INHIBITORS | CELLTECH THERAPEUTICS LIMITED (GB) | 1997-05-29 | — | — | WO | disclosed |