Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK4 | O00444 | 4/20 | 0.72 |
| ▸ | JAK2 | O60674 | 3/20 | 0.63 |
| ▸ | IGF1R | P08069 | 3/20 | 0.60 |
| ▸ | AURKA | O14965 | 2/20 | 0.57 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.57 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.56 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.56 |
| ▸ | ABL1 | P00519 | 2/20 | 0.55 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.55 |
| ▸ | YES1 | P07947 | 2/20 | 0.55 |
| ▸ | KDR | P35968 | 2/20 | 0.55 |
| ▸ | KDM1A | O60341 | 1/20 | 0.53 |
| ▸ | PIM1 | P11309 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | HIPK1 | Q86Z02 | 1/20 | 0.53 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.52 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.52 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.52 |
| ▸ | JAK3 | P52333 | 1/20 | 0.52 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27965372 | 0.83 | JAK2 (0.52) | PLK4JAK2AURKAAURKBABCG2 | |
| SCHEMBL28227359 | 0.82 | ROCK2 (0.61) | PLK4JAK2ABCG2 | |
| SCHEMBL28941887 | 0.80 | NPC1 (0.59) | PLK4AURKAAURKBABCG2KDR | |
| SCHEMBL2422608 | 0.79 | ABCG2 (0.72) | AURKAAURKBABCG2PIM1MAPK1 | |
| SCHEMBL6982507 | 0.79 | PLK4 (0.67) | PLK4JAK2IGF1RAURKAAURKB | |
| SCHEMBL28254694 | 0.78 | JAK2 (1.00) | PLK4JAK2MAPK8KDRMAPK10 | |
| SCHEMBL30855027 | 0.77 | PDE10A (0.64) | PLK4JAK2IGF1RAURKAAURKB | |
| SCHEMBL23906669 | 0.77 | PLK4 (0.69) | PLK4JAK2IGF1RAURKAAURKB | |
| SCHEMBL30086409 | 0.77 | PLK4 (0.69) | PLK4JAK2IGF1RAURKAAURKB | |
| SCHEMBL17660799 | 0.77 | TBK1 (0.73) | PLK4JAK2KDRMAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108601785-A | Purposes of the pyrimido pyridazinone in treating cancer | 阿沙纳生物科学公司 | 2018-09-28 | — | — | CN | claimed |
| CN-103974955-A | Pyrimido-pyridazinone compounds and uses thereof | ENDO PHARMACEUTICALS INC | 2014-08-06 | — | — | CN | claimed |
| WO-2018187294-A1 | PYRIMIDO-PYRIDAZINONE COMPOUND COMBINATIONS, METHODS, KITS AND FORMULATIONS THEREOF | ASANA BIOSCIENCES, LLC (US) | 2018-10-11 | — | — | WO | disclosed |