Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNRHR | P30968 | 12/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7839867 | 0.91 | GNRHR (0.55) | GNRHR | |
| SCHEMBL6986887 | 0.89 | GNRHR (0.51) | GNRHR | |
| SCHEMBL6982574 | 0.85 | GNRHR (0.48) | GNRHR | |
| SCHEMBL6983351 | 0.85 | GNRHR (0.51) | GNRHR | |
| SCHEMBL6984508 | 0.84 | GNRHR (0.49) | GNRHR | |
| SCHEMBL8020455 | 0.83 | GNRHR (0.67) | GNRHR | |
| SCHEMBL8665668 | 0.82 | GNRHR (0.45) | GNRHR | |
| SCHEMBL8191104 | 0.80 | PPARG (0.51) | GNRHR | |
| SCHEMBL6980627 | 0.79 | GNRHR (0.47) | GNRHR | |
| SCHEMBL6983015 | 0.79 | CXCR2 (0.55) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1095038-B1 | ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE | MERCK & CO INC (US) | 2003-09-03 | — | — | EP | disclosed |
| EP-0873336-B1 | ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE | MERCK & CO INC (US) | 2002-03-27 | — | — | EP | disclosed |
| US-6200957-B1 | USEFUL FOR TREATMENT OF VARIETY OF SEX-HORMONE RELATED AND OTHER CONDITIONS IN BOTH MEN AND WOMEN | MERCK & CO., INC. | 2001-03-13 | — | — | US | disclosed |
| US-6156767-A | Antagonists of gonadotropin releasing hormone | MERCK & CO., INC. (US) | 2000-12-05 | — | — | US | disclosed |
| EP-0994708-A1 | ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE | Merck & Co., Inc. (US) | 2000-04-26 | — | — | EP | disclosed |
| WO-1998055123-A1 | ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE | MERCK & CO., INC. (US) | 1998-12-10 | — | — | WO | disclosed |
| US-5780437-A | ADMINISTERING TO TREAT SEX-HORMONE RELATED DISORDERS | MERCK & CO., INC. (US) | 1998-07-14 | — | — | US | disclosed |