Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 2/20 | 0.39 |
| ▸ | GLP1R | P43220 | 3/20 | 0.39 |
| ▸ | CCR3 | P51677 | 10/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4943448 | 1.00 | CFTR (0.39) | CFTRGLP1RCCR3NPC1HTT | |
| SCHEMBL6977679 | 1.00 | CFTR (0.39) | CFTRGLP1RCCR3NPC1HTT | |
| SCHEMBL4943441 | 1.00 | CFTR (0.39) | CFTRGLP1RCCR3NPC1HTT | |
| SCHEMBL6980791 | 0.92 | CFTR (0.42) | CFTRGLP1RCCR3NPC1HTT | |
| SCHEMBL6980794 | 0.92 | CFTR (0.42) | CFTRGLP1RCCR3NPC1HTT | |
| SCHEMBL4942208 | 0.92 | CFTR (0.42) | CFTRGLP1RCCR3NPC1HTT | |
| SCHEMBL4942211 | 0.92 | CFTR (0.42) | CFTRGLP1RCCR3NPC1HTT | |
| SCHEMBL4939957 | 0.81 | STK4 (0.37) | CFTRCCR3NPC1HTTRAB9A | |
| SCHEMBL4939954 | 0.81 | STK4 (0.37) | CFTRCCR3NPC1HTTRAB9A | |
| SCHEMBL5478614 | 0.79 | CFTR (0.42) | CFTRCCR3NPC1HTTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268419-A1 | PYRROLIDINE DERIVATIVES USEFUL AS BAX INHIBITORS | Applied Research Systems ARS Holding N.V. (AN) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001072705-A1 | PHARMACEUTICALLY ACTIVE PYRROLIDINE DERIVATIVES AS BAX INHIBITORS | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2001-10-04 | — | — | WO | disclosed |