Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 5/20 | 0.42 |
| ▸ | PABPC1 | P11940 | 2/20 | 0.42 |
| ▸ | CCR3 | P51677 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | GLP1R | P43220 | 1/20 | 0.37 |
| ▸ | OXTR | P30559 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4942208 | 1.00 | CFTR (0.42) | CFTRPABPC1CCR3MEN1MAPT | |
| SCHEMBL4942211 | 1.00 | CFTR (0.42) | CFTRPABPC1CCR3MEN1MAPT | |
| SCHEMBL6980791 | 1.00 | CFTR (0.42) | CFTRPABPC1CCR3MEN1MAPT | |
| SCHEMBL6977679 | 0.92 | CFTR (0.39) | CFTRCCR3NPC1RAB9AHTT | |
| SCHEMBL4943441 | 0.92 | CFTR (0.39) | CFTRCCR3NPC1RAB9AHTT | |
| SCHEMBL6983329 | 0.92 | CFTR (0.39) | CFTRCCR3NPC1RAB9AHTT | |
| SCHEMBL4943448 | 0.92 | CFTR (0.39) | CFTRCCR3NPC1RAB9AHTT | |
| SCHEMBL4939957 | 0.85 | STK4 (0.37) | CFTRCCR3MEN1MAPTKMT2A | |
| SCHEMBL4939954 | 0.85 | STK4 (0.37) | CFTRCCR3MEN1MAPTKMT2A | |
| SCHEMBL4938908 | 0.84 | PABPC1 (0.45) | CFTRPABPC1MEN1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268418-A1 | PHARMACEUTICALLY ACTIVE PYRROLIDINE DERIVATIVES AS BAX INHIBITORS | Applied Research Systems ARS Holding N.V. (AN) | 2003-01-02 | — | — | EP | claimed |
| WO-2001074769-A1 | PHARMACEUTICALLY ACTIVE PYRROLIDINE DERIVATIVES AS BAX INHIBITORS | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2001-10-11 | — | — | WO | claimed |