Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.50 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | NR3C1 | P04150 | 9/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6984851 | 0.92 | BRD4 (0.50) | BRD4CREBBPSMN1; SMN2MAPTLMNA | |
| SCHEMBL6985746 | 0.89 | KMT2A (0.56) | BRD4CREBBPSMN1; SMN2MAPTLMNA | |
| SCHEMBL6977631 | 0.87 | BRD4 (0.56) | BRD4CREBBPSMN1; SMN2MAPTNR3C1 | |
| SCHEMBL6986216 | 0.87 | KMT2A (0.56) | BRD4CREBBPSMN1; SMN2MAPTLMNA | |
| Iodide SCHEMBL7959251 | 0.86 | NR3C1 (0.48) | BRD4CREBBPSMN1; SMN2MAPTLMNA | |
| SCHEMBL6985317 | 0.85 | NR3C1 (0.58) | SMN1; SMN2MAPTLMNANR3C1MEN1 | |
| SCHEMBL6978505 | 0.84 | BRD4 (0.45) | BRD4CREBBPSMN1; SMN2NR3C1PKM | |
| SCHEMBL6985865 | 0.84 | MAPT (0.56) | SMN1; SMN2MAPTLMNANR3C1PKM | |
| SCHEMBL6982759 | 0.84 | BRD4 (0.53) | BRD4CREBBPSMN1; SMN2MAPTLMNA | |
| SCHEMBL6984755 | 0.84 | TP53 (0.56) | SMN1; SMN2MAPTLMNANR3C1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0991624-B1 | PHENYLALKYL DERIVATIVES WITH THROMBIN-INHIBITING EFFECT | BOEHRINGER INGELHEIM PHARMA (DE) | 2003-11-19 | — | — | EP | disclosed |
| US-6300342-B1 | FOR THERAPY OR INHIBITING THROMBUS FORMATION; FOR THERAPY OF FIBRIN-DEPENDENT INFLAMMATORY CONDITION | BOEHRINGER INGELHEIM PHARM KG (DE) | 2001-10-09 | — | — | US | disclosed |
| EP-0991624-A1 | PHENYLALKYL DERIVATIVES WITH THROMBIN-INHIBITING EFFECT | Boehringer Ingelheim Pharma KG (DE) | 2000-04-12 | — | — | EP | disclosed |
| WO-1999000371-A1 | PHENYLALKYL DERIVATIVES WITH THROMBIN-INHIBITING EFFECT | BOEHRINGER INGELHEIM PHARMA KG (DE) | 1999-01-07 | — | — | WO | disclosed |