Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.68 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.68 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | HTT | P42858 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 3/20 | 0.50 |
| ▸ | GALR3 | O60755 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6988820 | 1.00 | SMN1; SMN2 (0.68) | SMN1; SMN2MAPK1MAPTALDH1A1KMT2A | |
| SCHEMBL1163936 | 0.87 | SMN1; SMN2 (0.66) | SMN1; SMN2MAPK1MAPTALDH1A1KMT2A | |
| SCHEMBL6985860 | 0.82 | KMT2A (0.74) | SMN1; SMN2MAPK1MAPTALDH1A1KMT2A | |
| SCHEMBL6988457 | 0.82 | KMT2A (0.74) | SMN1; SMN2MAPK1MAPTALDH1A1KMT2A | |
| SCHEMBL6988643 | 0.78 | SMN1; SMN2 (0.49) | SMN1; SMN2MAPK1MAPTALDH1A1KMT2A | |
| SCHEMBL1164483 | 0.78 | SMN1; SMN2 (0.61) | SMN1; SMN2MAPK1MAPTALDH1A1KMT2A | |
| SCHEMBL6987777 | 0.77 | SMN1; SMN2 (0.54) | SMN1; SMN2MAPK1MAPTALDH1A1KMT2A | |
| SCHEMBL13889022 | 0.77 | SMN1; SMN2 (0.64) | SMN1; SMN2MAPK1MAPTALDH1A1HTT | |
| SCHEMBL2981646 | 0.76 | SMN1; SMN2 (0.68) | SMN1; SMN2MAPK1MAPTALDH1A1KMT2A | |
| SCHEMBL1164041 | 0.75 | SMN1; SMN2 (0.58) | SMN1; SMN2MAPK1MAPTALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1341779-A2 | HETEROCYCLIC SULFONAMIDE INHIBITORS OF BETA AMYLOID PRODUCTION | Wyeth (US) | 2003-09-10 | — | — | EP | claimed |
| WO-2002057252-A2 | HETEROCYCLIC SULFONAMIDE INHIBITORS OF BETA AMYLOID PRODUCTION | WYETH (US) | 2002-07-25 | — | — | WO | claimed |