SCHEMBL6985860

SCHEMBL6985860

O=S(=O)(NCCCCCO)c1ccc(Cl)s1

nearest known ligand 0.74

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 5/20 0.74
SMN1; SMN2 Q16637 3/20 0.74
HTT P42858 3/20 0.74
MEN1 O00255 2/20 0.74
TSHR P16473 1/20 0.74
ALDH1A1 P00352 3/20 0.68
PSEN1 P49768 2/20 0.46
PSEN2 P49810 2/20 0.46
APH1B Q8WW43 2/20 0.46
NCSTN Q92542 2/20 0.46
APH1A Q96BI3 2/20 0.46
PSENEN Q9NZ42 2/20 0.46
CYP1A2 P05177 1/20 0.46
CYP3A4 P08684 1/20 0.46
CYP2C9 P11712 1/20 0.46
CYP2C19 P33261 1/20 0.46
MAPK1 P28482 1/20 0.46
MAPT P10636 2/20 0.43
HPGD P15428 2/20 0.42
GAA P10253 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6988457 1.00 KMT2A (0.74) KMT2ASMN1; SMN2HTTMEN1TSHR
SCHEMBL9871464 0.84 KMT2A (0.68) KMT2ASMN1; SMN2HTTMEN1TSHR
SCHEMBL6983808 0.82 SMN1; SMN2 (0.68) KMT2ASMN1; SMN2HTTMEN1TSHR
SCHEMBL6988820 0.82 SMN1; SMN2 (0.68) KMT2ASMN1; SMN2HTTMEN1TSHR
SCHEMBL6986543 0.78 KMT2A (0.52) KMT2ASMN1; SMN2HTTMEN1TSHR
SCHEMBL6989865 0.77 KMT2A (0.58) KMT2ASMN1; SMN2HTTMEN1TSHR
SCHEMBL5626348 0.77 KMT2A (0.58) KMT2ASMN1; SMN2HTTMEN1TSHR
SCHEMBL1287269 0.77 KMT2A (0.62) KMT2ASMN1; SMN2HTTMEN1TSHR
SCHEMBL6988610 0.76 KMT2A (0.51) KMT2ASMN1; SMN2HTTMEN1TSHR
SCHEMBL6985272 0.75 KMT2A (0.52) KMT2ASMN1; SMN2HTTMEN1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1341779-A2 HETEROCYCLIC SULFONAMIDE INHIBITORS OF BETA AMYLOID PRODUCTION Wyeth (US) 2003-09-10 EP claimed
WO-2002057252-A2 HETEROCYCLIC SULFONAMIDE INHIBITORS OF BETA AMYLOID PRODUCTION WYETH (US) 2002-07-25 WO claimed