Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 17/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11354470 | 0.85 | HTR6 (0.55) | CXCR2MEN1KMT2ADRD2HTR2A | |
| SCHEMBL11352581 | 0.81 | HTR6 (0.62) | CXCR2MEN1KMT2ACYP2C9 | |
| SCHEMBL7912408 | 0.81 | CYP1A2 (0.66) | CYP2C9 | |
| SCHEMBL7995810 | 0.80 | GNRHR (0.54) | — | |
| SCHEMBL8690925 | 0.77 | HTR6 (0.40) | — | |
| SCHEMBL8695357 | 0.77 | HTR1D (0.44) | CYP2C9 | |
| SCHEMBL6983015 | 0.76 | CXCR2 (0.55) | CXCR2CYP2C9 | |
| SCHEMBL6982096 | 0.76 | MAPT (0.46) | MEN1KMT2ACYP2C9DRD2HTR2A | |
| Hydrochloric Acid SCHEMBL8699219 | 0.75 | MAPT (0.45) | MEN1KMT2ACYP2C9DRD2HTR2A | |
| SCHEMBL8692594 | 0.73 | GNRHR (0.56) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1095038-B1 | ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE | MERCK & CO INC (US) | 2003-09-03 | — | — | EP | disclosed |
| EP-0873336-B1 | ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE | MERCK & CO INC (US) | 2002-03-27 | — | — | EP | disclosed |
| EP-1095038-A1 | ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE | Merck & Co., Inc. (US) | 2001-05-02 | — | — | EP | disclosed |
| US-6200957-B1 | USEFUL FOR TREATMENT OF VARIETY OF SEX-HORMONE RELATED AND OTHER CONDITIONS IN BOTH MEN AND WOMEN | MERCK & CO., INC. | 2001-03-13 | — | — | US | disclosed |
| WO-2000004013-A1 | ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE | MERCK & CO., INC. (US) | 2000-01-27 | — | — | WO | disclosed |
| EP-0873336-A1 | ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE | Merck & Co., Inc. (a New Jersey corp.) (US) | 1998-10-28 | — | — | EP | disclosed |
| US-5780437-A | ADMINISTERING TO TREAT SEX-HORMONE RELATED DISORDERS | MERCK & CO., INC. (US) | 1998-07-14 | — | — | US | disclosed |
| WO-1997021704-A1 | ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE | MERCK & CO., INC. (US) | 1997-06-19 | — | — | WO | disclosed |