Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHA2 | P29317 | 13/20 | 0.42 |
| ▸ | ERBB2 | P04626 | 6/20 | 0.42 |
| ▸ | KDR | P35968 | 13/20 | 0.42 |
| ▸ | EPHB4 | P54760 | 7/20 | 0.42 |
| ▸ | NSD2 | O96028 | 1/20 | 0.41 |
| ▸ | FLT1 | P17948 | 3/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 3/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | FYN | P06241 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | MET | P08581 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
| ▸ | LTK | P29376 | 1/20 | 0.39 |
| ▸ | TTK | P33981 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5828784 | 0.89 | EPHA2 (0.38) | EPHA2ERBB2KDREPHB4NSD2 | |
| SCHEMBL5828782 | 0.89 | EPHA2 (0.38) | EPHA2ERBB2KDREPHB4NSD2 | |
| SCHEMBL6984999 | 0.85 | EPHA2 (0.59) | EPHA2ERBB2KDREPHB4 | |
| SCHEMBL5828728 | 0.83 | EGFR (0.50) | KDRMAPK14EGFRAURKAALDH1A1 | |
| SCHEMBL5828729 | 0.83 | EGFR (0.50) | KDRMAPK14EGFRAURKAALDH1A1 | |
| SCHEMBL6985534 | 0.82 | EPHA2 (0.40) | EPHA2KDREPHB4MAPK14EGFR | |
| SCHEMBL4689343 | 0.81 | EPHA2 (0.47) | EPHA2ERBB2KDREPHB4NSD2 | |
| SCHEMBL5828872 | 0.81 | HTT (0.48) | KDRFLT1MAPK14EGFRALDH1A1 | |
| SCHEMBL5828868 | 0.81 | HTT (0.48) | KDRFLT1MAPK14EGFRALDH1A1 | |
| SCHEMBL6981726 | 0.79 | EPHA2 (0.57) | EPHA2KDREPHB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1296973-A1 | GUANIDINE DERIVATIVES OF QUINAZOLINE AND QUINOLINE FOR USE IN THE TREATMENT OF AUTOIMMUNE DISEASES | AstraZeneca AB (SE) | 2003-04-02 | — | — | EP | disclosed |
| WO-2002000644-A1 | GUANIDINE DERIVATIVES OF QUINAZOLINE AND QUINOLINE FOR USE IN THE TREATMENT OF AUTOIMMUNE DISEASES | ASTRAZENECA AB (SE) | 2002-01-03 | — | — | WO | disclosed |