Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHA2 | P29317 | 8/20 | 0.38 |
| ▸ | ERBB2 | P04626 | 5/20 | 0.38 |
| ▸ | KDR | P35968 | 7/20 | 0.38 |
| ▸ | EPHB4 | P54760 | 4/20 | 0.38 |
| ▸ | ACHE | P22303 | 2/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | NSD2 | O96028 | 1/20 | 0.36 |
| ▸ | KIT | P10721 | 5/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | FLT1 | P17948 | 3/20 | 0.35 |
| ▸ | KDM1A | O60341 | 2/20 | 0.35 |
| ▸ | EHMT2 | Q96KQ7 | 2/20 | 0.35 |
| ▸ | RCOR1 | Q9UKL0 | 2/20 | 0.35 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.35 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.35 |
| ▸ | KMT5A | Q9NQR1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5828782 | 1.00 | EPHA2 (0.38) | EPHA2ERBB2KDREPHB4ACHE | |
| SCHEMBL6983822 | 0.89 | EPHA2 (0.42) | EPHA2ERBB2KDREPHB4NSD2 | |
| SCHEMBL5828059 | 0.85 | EPHA2 (0.54) | EPHA2ERBB2KDREPHB4KIT | |
| SCHEMBL5828061 | 0.85 | EPHA2 (0.54) | EPHA2ERBB2KDREPHB4KIT | |
| SCHEMBL5828595 | 0.82 | EPHA2 (0.36) | EPHA2KDREPHB4MAPK14 | |
| SCHEMBL5828594 | 0.82 | EPHA2 (0.36) | EPHA2KDREPHB4MAPK14 | |
| SCHEMBL4689343 | 0.80 | EPHA2 (0.47) | EPHA2ERBB2KDREPHB4NSD2 | |
| SCHEMBL5829045 | 0.79 | EPHA2 (0.52) | EPHA2KDREPHB4KIT | |
| SCHEMBL5829043 | 0.79 | EPHA2 (0.52) | EPHA2KDREPHB4KIT | |
| SCHEMBL5828492 | 0.76 | RET (0.41) | KDRFLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7001904-B1 | Guanidine derivatives quinazoline and quinoline for use in the treatment of autoimmune diseases | ASTRAZENECA AB (SE) | 2006-02-21 | — | — | US | disclosed |
| EP-1296973-A1 | GUANIDINE DERIVATIVES OF QUINAZOLINE AND QUINOLINE FOR USE IN THE TREATMENT OF AUTOIMMUNE DISEASES | AstraZeneca AB (SE) | 2003-04-02 | — | — | EP | disclosed |
| WO-2002000644-A1 | GUANIDINE DERIVATIVES OF QUINAZOLINE AND QUINOLINE FOR USE IN THE TREATMENT OF AUTOIMMUNE DISEASES | ASTRAZENECA AB (SE) | 2002-01-03 | — | — | WO | disclosed |