Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 6/20 | 0.56 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | USP2 | O75604 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | GLA | P06280 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | TYMS | P04818 | 7/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28017671 | 0.87 | IP6K1 (0.71) | PARP1TNKS2KDM4ENPC1RAB9A | |
| SCHEMBL18681236 | 0.84 | IP6K1 (0.59) | PARP1TNKS2KDM4ENPC1RAB9A | |
| SCHEMBL19773889 | 0.84 | IP6K1 (0.59) | PARP1TNKS2KDM4ENPC1RAB9A | |
| SCHEMBL6985209 | 0.80 | KDM4E (0.42) | KDM4ENPC1RAB9AALDH1A1MAPT | |
| SCHEMBL17460813 | 0.80 | PARP1 (0.62) | PARP1TNKS2KDM4ENPC1RAB9A | |
| SCHEMBL30704851 | 0.80 | PARP1 (0.62) | PARP1TNKS2KDM4ENPC1RAB9A | |
| SCHEMBL889055 | 0.78 | CYP2A6 (0.44) | KDM4ENPC1RAB9AUSP2ALDH1A1 | |
| SCHEMBL31271793 | 0.78 | IP6K1 (0.52) | PARP1TNKS2KDM4ENPC1RAB9A | |
| SCHEMBL3226572 | 0.77 | TYMS (0.63) | PARP1TNKS2KDM4ENPC1RAB9A | |
| SCHEMBL29440611 | 0.77 | TYMS (0.63) | PARP1TNKS2KDM4ENPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100324029-A1 | THERAPEUTIC AGENTS | MERCK SHARP & DOHME CORP. | 2010-12-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100324029-A1 | THERAPEUTIC AGENTS | PSEN2, PSEN1, BACE2 | PARP1 1371/4885TNKS2 1469/4885KDM4E 3970/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.