Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADCY10 | Q96PN6 | 2/20 | 0.48 |
| ▸ | SLC2A1 | P11166 | 3/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.40 |
| ▸ | GSK3B | P49841 | 2/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | RAF1 | P04049 | 1/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.38 |
| ▸ | IGF1R | P08069 | 1/20 | 0.38 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 2/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.36 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5384464 | 0.81 | MAPK14 (0.60) | MAPK14GSK3BADORA2AEGFRRAF1 | |
| SCHEMBL8810385 | 0.80 | ADORA2A (0.53) | ADCY10MAPK14GSK3BADORA2AEGFR | |
| SCHEMBL3542508 | 0.75 | GSK3B (0.46) | ADCY10SLC2A1MAPK14GSK3BADORA2A | |
| SCHEMBL3278407 | 0.73 | ADCY10 (0.41) | ADCY10MAPK14GSK3BADORA2AEGFR | |
| SCHEMBL5388606 | 0.71 | GSK3B (0.54) | SLC2A1MAPK14GSK3BADORA2AEGFR | |
| SCHEMBL3534269 | 0.70 | SLC2A1 (0.55) | SLC2A1GSK3BAURKAKDRAURKB | |
| SCHEMBL3271643 | 0.69 | CDK4 (0.44) | ADCY10MAPK14ADORA2AMAPK1AURKA | |
| SCHEMBL3441833 | 0.68 | MAPK1 (0.43) | ADCY10SLC2A1MAPK14GSK3BADORA2A | |
| SCHEMBL14515749 | 0.67 | MAPK14 (0.41) | ADCY10SLC2A1MAPK14GSK3BADORA2A | |
| SCHEMBL3534340 | 0.67 | MAPK1 (0.41) | ADCY10SLC2A1MAPK14GSK3BADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1311507-A1 | FUSED PYRAZOLE DERIVATIVES BEING PROTEIN KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2003-05-21 | — | — | EP | disclosed |
| WO-2002016359-A1 | FUSED PYRAZOLE DERIVATIVES BEING PROTEIN KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2002-02-28 | — | — | WO | disclosed |