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ADCY10

Adenylate cyclase type 10 · Q96PN6 · ADCY10 on Sugi Atlas →

2,812 patent compounds predicted against ADCY10, 1,718 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL3949989 SCHEMBL3949989 0.44 9/20
SCHEMBL3718901 SCHEMBL3718901 0.54 8/20
SCHEMBL3951667 SCHEMBL3951667 0.63 7/20
SCHEMBL3952703 SCHEMBL3952703 0.43 7/20
SCHEMBL4221151 SCHEMBL4221151 0.51 6/20
SCHEMBL3715977 SCHEMBL3715977 0.48 6/20
SCHEMBL3946848 SCHEMBL3946848 0.46 6/20
SCHEMBL6265329 SCHEMBL6265329 0.44 6/20
SCHEMBL1998718 SCHEMBL1998718 0.42 6/20
SCHEMBL5064889 SCHEMBL5064889 0.38 6/20
SCHEMBL4286975 SCHEMBL4286975 0.57 5/20
SCHEMBL3141406 SCHEMBL3141406 0.44 5/20
SCHEMBL4033663 SCHEMBL4033663 0.40 5/20
SCHEMBL3944554 SCHEMBL3944554 0.57 4/20
SCHEMBL3946991 SCHEMBL3946991 0.48 4/20
SCHEMBL3943279 SCHEMBL3943279 0.46 4/20
SCHEMBL7606821 SCHEMBL7606821 0.46 4/20
SCHEMBL3944466 SCHEMBL3944466 0.45 4/20
SCHEMBL3946201 SCHEMBL3946201 0.44 4/20
SCHEMBL1318867 SCHEMBL1318867 0.41 4/20

Clinical trials — most relevant to ADCY10 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Pentoxifylline as an Adjunctive in Treatment of Negative Symptoms in Chronic Schizophrenia PHASE1/PHASE2COMPLETED
Carbidopa-levodopa in Neovascular AMD PHASE2COMPLETED
Safety Evaluation of Gene Therapy in Leber Hereditary Optic Neuropathy (LHON) Patients PHASE1/PHASE2COMPLETED
Discovery and Validation of Genetic Variants Affecting Microglial Activation in Alzheimer's Disease PHASE2ACTIVE_NOT_RECRUITING
Sodium Citrate in Smell Retraining for People With Post-COVID-19 Olfactory Dysfunction PHASE2ACTIVE_NOT_RECRUITING
Effect of Gene Variants on Dopamine Receptor Natriuretic Responses PHASE1UNKNOWN
PET Brain and Whole Body Distribution Studies for Nociceptin/Orphanin FQ Peptide (NOP) Receptor Using [11C]NOP-1A EARLY_PHASE1COMPLETED
Caffeine Efficacy in ADCY5-related Dyskinesia nanUNKNOWN
Pilot Study on Caffeine Efficiency in ADCY5-related Dyskinesia nanCOMPLETED
Assessment of ADCY5-related Movement Disorders With Motion SENSors nanCOMPLETED
Genetics of Endocrine Tumours - Familial Isolated Pituitary Adenoma - FIPA nanRECRUITING
Phenotypic and Genotypic Studies in Congenital and Early Onset Ataxias nanCOMPLETED
Identifying Genes and Mutations Underlying Retinitis Pigmentosa and Allied Diseases nanUNKNOWN
Biomarker Research in Inherited Movement Disorders nanRECRUITING
Stress and Treatment Response in Puerto Rican Children With Asthma nanCOMPLETED
The Effects of a Long-lasting Infusion of Vasoactive Intestinal Peptide (VIP) in Episodic Migraine Patients nanCOMPLETED
Core Stability Exercises and Hereditary Ataxia nanCOMPLETED
Intravenous Terbutaline in Severe Status Asthmaticus nanUNKNOWN
Effect of Intraperitoneal Bupivacaine with Dexmedotomidine or Fentanyl for Post-Operative Analgesia Following Laparoscopy in Pediatric Patients nanNOT_YET_RECRUITING
Genetic Characterization of Parkinson's Disease nanCOMPLETED
Classification, Functional Stratification and Biomarkers in Ciliopathy (CILLICORIRCM) nanCOMPLETED
Mechanisms of Inherited Retinal Dystrophies Using Whole Genome Sequencing and in Vitro and in Vivo Models nanCOMPLETED
PACAP Induced Migraine Attacks in Patients With High and Low Genetic Load nanCOMPLETED
The Application of 68Ga-Pentixafor Alongside 68Ga-FAPI-04 PET/MR for Assessing Primary Aldosteronism. nanNOT_YET_RECRUITING
Investigating Phenotypic, Epigenetic, and NeuroGenetic Traits in Rare and Ultra-rare Neurodevelopmental Disorders (Project PENGUIN) nanRECRUITING
Role of Polymorphisms in the IL-1 Gene Cluster nanCOMPLETED
Genetic Analyses of Nonsyndromic and Syndromic Deafness in Pakistan nanENROLLING_BY_INVITATION
PCD New Gene Discovery nanCOMPLETED
Genetic Study of Age-Related Macular Degeneration nanCOMPLETED
Identification of Genetic Basis of Atrioventricular Conduction Defects: From Congenital Forms to Degenerative Forms nanUNKNOWN

Related proteins — ESM-2 sequence neighbours (a ADCY10 binder may also engage these)

ProteinNameSimilarity
Q866F4 — 0.999 Q866F4 →
Q8C0T9 — 0.998 Q8C0T9 →
Q9Z286 — 0.996 Q9Z286 →
Q6P3V7 — 0.974 Q6P3V7 →
B1ARD8 — 0.972 B1ARD8 →
Q8IV35 — 0.971 Q8IV35 →
Q692V3 — 0.971 Q692V3 →
Q6P2S7 — 0.970 Q6P2S7 →
Q9CUL5 — 0.969 Q9CUL5 →
PDE5A cGMP-specific 3',5'-cyclic phosphodiesterase 0.969 landscape →
Q8CEL2 — 0.968 Q8CEL2 →
Q86VS3 — 0.967 Q86VS3 →
Q9D565 — 0.967 Q9D565 →
Q8C0W1 — 0.967 Q8C0W1 →
Q68D06 — 0.967 Q68D06 →
PARP9 Protein mono-ADP-ribosyltransferase PARP9 0.967 landscape →
ORC3 Origin recognition complex subunit 3 0.967 landscape →
Q5K651 — 0.966 Q5K651 →
Q5DJU3 — 0.966 Q5DJU3 →
O02789 — 0.966 O02789 →
B1ARD6 — 0.966 B1ARD6 →
Q8NE18 — 0.966 Q8NE18 →
Q8IVG5 — 0.966 Q8IVG5 →
Q28156 — 0.966 Q28156 →
Q8K441 — 0.966 Q8K441 →
SLFN12 Ribonuclease SLFN12 0.966 landscape →
O54735 — 0.965 O54735 →
Q008S8 — 0.965 Q008S8 →
Q8NA54 — 0.965 Q8NA54 →
Q9GLV6 — 0.965 Q9GLV6 →