Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 5/20 | 0.44 |
| ▸ | LPAR3 | Q9UBY5 | 3/20 | 0.44 |
| ▸ | LPAR2 | Q9HBW0 | 2/20 | 0.39 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.39 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.39 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.39 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | ABCB4 | P21439 | 1/20 | 0.39 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.39 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.39 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.38 |
| ▸ | GBA1 | P04062 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6364 | 0.80 | LPAR1 (0.42) | LPAR1LPAR3LPAR2ABCC3ABCC4 | |
| SCHEMBL6983 | 0.78 | LPAR1 (0.45) | LPAR1LPAR3LPAR2ABCC3ABCC4 | |
| SCHEMBL7648 | 0.76 | MEN1 (0.44) | LPAR1LPAR3ABCC3ABCC4ABCB11 | |
| SCHEMBL1166 | 0.76 | LPAR1 (0.47) | LPAR1LPAR3LPAR2ABCC3ABCC4 | |
| SCHEMBL1445 | 0.73 | TSHR (0.44) | LPAR1LPAR3TP53HDAC3 | |
| SCHEMBL1406 | 0.73 | LPAR1 (0.40) | LPAR1LPAR3LPAR2ABCC3ABCC4 | |
| SCHEMBL4347 | 0.72 | LPAR1 (0.46) | LPAR1LPAR3LPAR2ABCC3ABCC4 | |
| SCHEMBL1165 | 0.72 | KMT2A (0.45) | LPAR1LPAR3LPAR2ABCC3ABCC4 | |
| SCHEMBL4348 | 0.72 | IGF1R (0.43) | LPAR1LPAR3MAPTKDM4ESMN1; SMN2 | |
| SCHEMBL15897157 | 0.71 | LPAR1 (0.45) | LPAR1LPAR3LPAR2ABCC3ABCC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2483252-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | Amira Pharmaceuticals, Inc. (US) | 2012-08-08 | — | — | EP | disclosed |
| WO-2011041694-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS, INC. (US) | 2011-04-07 | — | — | WO | disclosed |