Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.71 |
| ▸ | PKM | P14618 | 1/20 | 0.71 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.55 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.52 |
| ▸ | KDR | P35968 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | RORC | P51449 | 1/20 | 0.49 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.48 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.48 |
| ▸ | NAMPT | P43490 | 1/20 | 0.48 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25195749 | 0.84 | KDM4E (0.61) | KDM4EPKMUSP30TP53RORC | |
| SCHEMBL13391117 | 0.84 | GPR119 (0.60) | KDM4EPKMGPR119USP30KDR | |
| SCHEMBL30740815 | 0.83 | GPR119 (0.56) | KDM4EPKMGPR119USP30KDR | |
| SCHEMBL8063381 | 0.83 | USP30 (0.68) | GPR119USP30KDRLMNAEPHX1 | |
| SCHEMBL26131403 | 0.83 | KDM4E (1.00) | KDM4EPKMGPR119TP53TGFBR1 | |
| SCHEMBL3035919 | 0.82 | GRIN2B (0.68) | KDM4EPKMGPR119TGFBR1GRIN2B | |
| SCHEMBL8206262 | 0.82 | KDM4E (0.64) | KDM4EPKMGPR119TP53RORC | |
| SCHEMBL7467887 | 0.82 | KDM4E (0.64) | KDM4EPKMGPR119TP53LMNA | |
| SCHEMBL22594810 | 0.81 | KDM4E (0.59) | KDM4EPKMGPR119LMNATGFBR1 | |
| SCHEMBL6981253 | 0.81 | KDM4E (0.62) | KDM4EPKMGPR119TP53LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0839145-B1 | HETEROCYCLYLCARBOXAMIDE DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS | ABBOTT GMBH & CO KG (DE) | 2003-11-05 | — | — | EP | disclosed |
| EP-0876372-B1 | HETEROARYLCARBOXAMIDE DERIVATIVES | KNOLL GMBH (DE) | 2002-03-06 | — | — | EP | disclosed |
| CN-1071755-C | Heterocyclylcarboxamide derivatives and their use as therapeutic agents | KNOLL AG (DE) | 2001-09-26 | — | — | CN | disclosed |
| US-5935973-A | AFFINITY FOR 5-HT1A, ALPHA1, ALPHA2 AND/OR D2 RECEPTORS; ANTIDEPRESSANTS, ANXIOLYTIC AGENTS, PSYCHOSES, DYSKINESIAS, PARKINSON'S DISEASE, HYPOTENSIVE AGENTS, TOURETTE'S SYNDROME, OBSESSIVE-COMPULSIVE BEHAVIOUR, PANIC ATTACKS, SOCIAL PHOBIAS | KNOLL AKTIENGESELLSCHAFT (DE) | 1999-08-10 | — | — | US | disclosed |
| CN-1190967-A | Heterocyclylcarboxamide derivatives and their use as therapeutic agents | KNOLL AG (DE) | 1998-08-19 | — | — | CN | disclosed |
| EP-0840763-A1 | CROSS-LINKED ELASTOMER CAPABLE OF THERMOPLASTIC TRANSFORMATION, METHOD OF MANUFACTURE AND USES THEREOF | HUTCHINSON (FR) | 1998-05-13 | — | — | EP | disclosed |
| EP-0839145-A1 | HETEROCYCLYLCARBOXAMIDE DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS | Knoll AG (DE) | 1998-05-06 | — | — | EP | disclosed |
| WO-1997044390-A1 | CROSS-LINKED ELASTOMER CAPABLE OF THERMOPLASTIC TRANSFORMATION, METHOD OF MANUFACTURE AND USES THEREOF | HUTCHINSON (FR) | 1997-11-27 | — | — | WO | disclosed |
| WO-1997003071-A1 | HETEROCYCLYLCARBOXAMIDE DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS | KNOLL AKTIENGESELLSCHAFT (DE) | 1997-01-30 | — | — | WO | disclosed |