Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIMK1 | P53667 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.37 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | KDM6B | O15054 | 1/20 | 0.36 |
| ▸ | KDM6A | O15550 | 1/20 | 0.36 |
| ▸ | TET3 | O43151 | 1/20 | 0.36 |
| ▸ | KDM4A | O75164 | 1/20 | 0.36 |
| ▸ | KDM4B | O94953 | 1/20 | 0.36 |
| ▸ | KDM5C | P41229 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10507045 | 0.78 | LIMK1 (0.55) | LIMK1LMNACYP2C9CYP2C19KDM4E | |
| SCHEMBL27404716 | 0.78 | LIMK1 (0.55) | LIMK1LMNAKDM4EALDH1A1GPR35 | |
| SCHEMBL8507168 | 0.76 | LIMK1 (0.77) | LIMK1LMNAKDM4EALDH1A1MCL1 | |
| SCHEMBL1098450 | 0.76 | LIMK1 (0.54) | LIMK1LMNAKDM4EALDH1A1MCL1 | |
| SCHEMBL7508777 | 0.74 | CYP2C9 (0.46) | LIMK1LMNACYP2C9CYP2C19KDM4E | |
| SCHEMBL13736548 | 0.74 | MCL1 (0.57) | LIMK1LMNACYP2C9CYP2C19KDM4E | |
| SCHEMBL2895816 | 0.73 | LIMK1 (0.50) | LIMK1LMNAKDM4EALDH1A1GPR35 | |
| SCHEMBL4859707 | 0.73 | LIMK1 (0.50) | LIMK1LMNAKDM4EALDH1A1MCL1 | |
| SCHEMBL29631384 | 0.72 | LIMK1 (0.49) | LIMK1LMNAKDM4EALDH1A1GPR35 | |
| SCHEMBL21813696 | 0.72 | LIMK1 (0.56) | LIMK1LMNACYP2C9CYP2C19KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1093367-A4 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2003-03-05 | — | — | EP | disclosed |
| EP-1093367-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-04-25 | — | — | EP | disclosed |
| WO-1999066925-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-12-29 | — | — | WO | disclosed |