Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIMK1 | P53667 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | KDM6B | O15054 | 1/20 | 0.36 |
| ▸ | KDM6A | O15550 | 1/20 | 0.36 |
| ▸ | TET3 | O43151 | 1/20 | 0.36 |
| ▸ | KDM4A | O75164 | 1/20 | 0.36 |
| ▸ | KDM4B | O94953 | 1/20 | 0.36 |
| ▸ | KDM5C | P41229 | 1/20 | 0.36 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.36 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8142918 | 0.85 | LIMK1 (0.48) | LIMK1KDM4EKMT2ALMNATDP1 | |
| SCHEMBL27404716 | 0.78 | LIMK1 (0.55) | LIMK1KDM4EKMT2AMCL1LMNA | |
| SCHEMBL10507045 | 0.78 | LIMK1 (0.55) | LIMK1KDM4EKMT2AMCL1LMNA | |
| SCHEMBL8507168 | 0.76 | LIMK1 (0.77) | LIMK1KDM4EKMT2AMCL1LMNA | |
| SCHEMBL1098450 | 0.76 | LIMK1 (0.54) | LIMK1KDM4EKMT2AMCL1LMNA | |
| SCHEMBL4859707 | 0.76 | LIMK1 (0.50) | LIMK1KDM4EKMT2AMCL1NPC1 | |
| SCHEMBL2896096 | 0.76 | KDM4E (0.52) | LIMK1KDM4EKMT2ALMNATDP1 | |
| SCHEMBL6984157 | 0.73 | LIMK1 (0.50) | LIMK1KDM4EKMT2AMCL1LMNA | |
| SCHEMBL29631384 | 0.72 | LIMK1 (0.49) | LIMK1KDM4EKMT2AMCL1NPC1 | |
| SCHEMBL4125992 | 0.71 | PTPN1 (0.56) | LIMK1KDM4EKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7732477-B2 | N-(1-azabicyclo[2.2.2]oct-3-yl)-heteroaryl carboxamides; alpha 7-nicotinic acetylcholine receptors (nAChR) agonists; improving perception, concentration, learning and memory; neuropathic pain; acute and chronic pain | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2010-06-08 | — | — | US | disclosed |