Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 11/20 | 0.72 |
| ▸ | GLA | P06280 | 1/20 | 0.69 |
| ▸ | GAA | P10253 | 1/20 | 0.69 |
| ▸ | SULT1A1 | P50225 | 1/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.62 |
| ▸ | NPC1 | O15118 | 1/20 | 0.62 |
| ▸ | PKM | P14618 | 1/20 | 0.62 |
| ▸ | RAB9A | P51151 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.62 |
| ▸ | SNCA | P37840 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5429982 | 0.93 | APP (0.83) | APPGLAGAASULT1A1KDM4E | |
| SCHEMBL21752042 | 0.90 | APP (0.74) | APPGLAGAASULT1A1KDM4E | |
| SCHEMBL299010 | 0.88 | CYP1A2 (0.67) | APPGLAGAANPC1RAB9A | |
| SCHEMBL5419850 | 0.87 | SULT1A1 (0.70) | APPGLAGAASULT1A1KDM4E | |
| SCHEMBL26017584 | 0.85 | APP (0.76) | APPGLAGAASULT1A1SNCA | |
| SCHEMBL1983003 | 0.84 | APP (0.71) | APPGLAGAASULT1A1KDM4E | |
| SCHEMBL23766560 | 0.84 | APP (0.74) | APPGLAGAASULT1A1KDM4E | |
| SCHEMBL1572680 | 0.84 | APP (1.00) | APPGLAGAASULT1A1 | |
| SCHEMBL4801119 | 0.84 | SULT1A1 (0.84) | APPGLAGAASULT1A1SMN1; SMN2 | |
| SCHEMBL1572797 | 0.84 | APP (0.74) | APPGLAGAASULT1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1345914-A1 | THERAPEUTIC COMPOUNDS | AstraZeneca AB (SE) | 2003-09-24 | — | — | EP | disclosed |
| WO-2002051821-A1 | THERAPEUTIC COMPOUNDS | ASTRAZENECA AB (SE) | 2002-07-04 | — | — | WO | disclosed |