Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | CCR6 | P51684 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 4/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6993433 | 0.93 | ALDH1A1 (0.46) | ALDH1A1KDM4EPKMMAPK1MAPT | |
| SCHEMBL18287264 | 0.91 | ALDH1A1 (0.41) | ALDH1A1KDM4EGAAMAPTKMT2A | |
| SCHEMBL18994283 | 0.86 | MAPT (0.51) | ALDH1A1KDM4EPKMMAPK1MAPT | |
| SCHEMBL6989385 | 0.76 | MAOB (0.43) | MAPTMAOBNPSR1ALOX5 | |
| SCHEMBL6987060 | 0.74 | APP (0.40) | ALDH1A1PKMMAPK1MAPTKMT2A | |
| SCHEMBL13192022 | 0.74 | ALDH1A1 (0.37) | ALDH1A1KDM4EPKMMAPK1MAPT | |
| SCHEMBL7212650 | 0.73 | CYP1A2 (0.46) | ALDH1A1PKMMAPTNPSR1 | |
| SCHEMBL6989242 | 0.73 | CYP1A2 (0.46) | ALDH1A1PKMMAPTNPSR1 | |
| SCHEMBL6984471 | 0.71 | MAOB (0.41) | ALDH1A1KDM4EMAPK1MAPTKMT2A | |
| SCHEMBL6987510 | 0.71 | CYP1A2 (0.56) | MAPTKMT2AMEN1MAOBNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9439877-B2 | Small molecule inhibitors of Dusp6 and uses therefor | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2016-09-13 | — | — | US | disclosed |
| US-20160113889-A1 | Small Molecule Inhibitors of Dusp6 and Uses Therefor | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2016-04-28 | — | — | US | disclosed |
| US-9127016-B2 | Small molecule inhibitors of Dusp6 and uses therefor | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2015-09-08 | — | — | US | disclosed |
| US-20120122992-A1 | SMALL MOLECULE INHIBITORS OF Dusp6 AND USES THEREFOR | University of Pittsburgh-Of the Commonwealth Syste (US) | 2012-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160113889-A1 | Small Molecule Inhibitors of Dusp6 and Uses Therefor | DUSP26, DUSP6, DUSP2 | ALDH1A1 1760/4885KDM4E 2719/4885PKM 4238/4885 |
| US-20120122992-A1 | SMALL MOLECULE INHIBITORS OF Dusp6 AND USES THEREFOR | DUSP26, DUSP6, DUSP2 | ALDH1A1 1760/4885KDM4E 2719/4885PKM 4238/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.