Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 14/20 | 0.64 |
| ▸ | HTR1A | P08908 | 3/20 | 0.56 |
| ▸ | HTR2C | P28335 | 3/20 | 0.56 |
| ▸ | DRD3 | P35462 | 2/20 | 0.56 |
| ▸ | HTR7 | P34969 | 2/20 | 0.56 |
| ▸ | HTR2A | P28223 | 2/20 | 0.56 |
| ▸ | DRD2 | P14416 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.49 |
| ▸ | KHK | P50053 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10874677 | 0.90 | HTR6 (0.57) | HTR6HTR1AHTR2CDRD3HTR7 | |
| SCHEMBL16260562 | 0.90 | HTR6 (0.56) | HTR6HTR1AHTR2CDRD3HTR7 | |
| SCHEMBL14406061 | 0.86 | HTR6 (0.56) | HTR6HTR1AHTR2CDRD3HTR7 | |
| SCHEMBL7138867 | 0.80 | HTR6 (0.60) | HTR6HTR1AHTR2CDRD3HTR7 | |
| SCHEMBL27557297 | 0.80 | HTR6 (0.60) | HTR6HTR1AHTR2CDRD3HTR7 | |
| SCHEMBL27336067 | 0.80 | HTR6 (0.60) | HTR6HTR1AHTR2CDRD3HTR7 | |
| SCHEMBL9462735 | 0.76 | HTR6 (0.68) | HTR6HTR1AHTR2CDRD3HTR7 | |
| SCHEMBL12177017 | 0.75 | KDM4E (0.64) | HTR7KDM4EALDH1A1 | |
| SCHEMBL9147029 | 0.73 | HTR6 (0.56) | HTR6 | |
| SCHEMBL9149499 | 0.73 | HTR6 (0.52) | HTR6HTR1AHTR2CDRD3KHK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0923575-B1 | CYCLIC ETHER COMPOUNDS AS SODIUM CHANNEL MODULATORS | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-03-12 | — | — | EP | disclosed |
| US-6172085-B1 | CENTRAL NERVOUS SYSTEM AND PSYCHOLOGICAL DISORDERS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-01-09 | — | — | US | disclosed |
| EP-0923575-A1 | CYCLIC ETHER COMPOUNDS AS SODIUM CHANNEL MODULATORS | Takeda Chemical Industries, Ltd. (JP) | 1999-06-23 | — | — | EP | disclosed |
| WO-1998008842-A1 | CYCLIC ETHER COMPOUNDS AS SODIUM CHANNEL MODULATORS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-03-05 | — | — | WO | disclosed |