Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 4/20 | 0.48 |
| ▸ | HTR2A | P28223 | 3/20 | 0.40 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.39 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.39 |
| ▸ | CTSC | P53634 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 6/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | ATM | Q13315 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 5/20 | 0.36 |
| ▸ | POLB | P06746 | 4/20 | 0.36 |
| ▸ | RECQL | P46063 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | REN | P00797 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6986484 | 1.00 | ADAM17 (0.48) | ADAM17HTR2AGRIK1GRIK2CTSC | |
| SCHEMBL6220493 | 1.00 | ADAM17 (0.48) | ADAM17HTR2AGRIK1GRIK2CTSC | |
| SCHEMBL6220497 | 1.00 | ADAM17 (0.48) | ADAM17HTR2AGRIK1GRIK2CTSC | |
| SCHEMBL6220496 | 1.00 | ADAM17 (0.48) | ADAM17HTR2AGRIK1GRIK2CTSC | |
| SCHEMBL6220502 | 1.00 | ADAM17 (0.48) | ADAM17HTR2AGRIK1GRIK2CTSC | |
| SCHEMBL7847702 | 0.92 | ADAM17 (0.43) | ADAM17HTR2AGRIK1GRIK2CTSC | |
| SCHEMBL7847705 | 0.92 | ADAM17 (0.43) | ADAM17HTR2AGRIK1GRIK2CTSC | |
| SCHEMBL6223927 | 0.88 | ADAM17 (0.45) | ADAM17HTR2AGRIK1GRIK2MAPT | |
| SCHEMBL6223932 | 0.88 | ADAM17 (0.45) | ADAM17HTR2AGRIK1GRIK2MAPT | |
| SCHEMBL6220557 | 0.88 | ADAM17 (0.45) | ADAM17HTR2AGRIK1GRIK2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1089964-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-10-29 | — | — | EP | disclosed |
| US-6239151-B1 | TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES, OSTEOARTHRITIS, RESPIRATORY DISEASES, TUMORS, CACHEXIA, CARDIOVASCULAR DISEASES, FEVER, HAEMORRHAGE AND SEPSIS, HYDRAZINE DERIVATIVES, | HOFFMANN-LA ROCHE INC. | 2001-05-29 | — | — | US | disclosed |
| EP-1089964-A1 | HYDRAZINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2001-04-11 | — | — | EP | disclosed |
| WO-2000000465-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-01-06 | — | — | WO | disclosed |