Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 1/20 | 0.76 |
| ▸ | HTR7 | P34969 | 7/20 | 0.62 |
| ▸ | HTR6 | P50406 | 1/20 | 0.56 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.53 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.53 |
| ▸ | CDK4 | P11802 | 3/20 | 0.52 |
| ▸ | CCND1 | P24385 | 3/20 | 0.52 |
| ▸ | DRD2 | P14416 | 1/20 | 0.49 |
| ▸ | DRD4 | P21917 | 1/20 | 0.49 |
| ▸ | DRD3 | P35462 | 1/20 | 0.49 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5840496 | 0.99 | ABCB1 (0.74) | ABCB1HTR7HTR6SIGMAR1TMEM97 | |
| SCHEMBL5842531 | 0.98 | ABCB1 (0.80) | ABCB1HTR7HTR6SIGMAR1TMEM97 | |
| Hydrochloric Acid SCHEMBL5840985 | 0.96 | ABCB1 (0.78) | ABCB1HTR7HTR6SIGMAR1TMEM97 | |
| SCHEMBL6983441 | 0.93 | HTR7 (0.71) | ABCB1HTR7HTR6SIGMAR1TMEM97 | |
| Hydrochloric Acid SCHEMBL5842626 | 0.92 | HTR7 (0.70) | ABCB1HTR7HTR6SIGMAR1TMEM97 | |
| SCHEMBL12124562 | 0.86 | ABCB1 (1.00) | ABCB1HTR7SIGMAR1TMEM97CDK4 | |
| SCHEMBL6978580 | 0.82 | HTR7 (0.88) | ABCB1HTR7HTR6SIGMAR1 | |
| SCHEMBL6975705 | 0.80 | HTR7 (0.64) | ABCB1HTR7HTR6SIGMAR1 | |
| SCHEMBL13885187 | 0.80 | CDK4 (0.61) | ABCB1SIGMAR1CDK4CCND1DRD2 | |
| SCHEMBL13884903 | 0.80 | CDK4 (0.61) | ABCB1SIGMAR1CDK4CCND1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1275647-B1 | Octahydro-2H-pyrido[1,2-a]pyrazine derivatives, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2003-11-12 | — | — | EP | disclosed |
| EP-1275647-A1 | Octahydro-2H-pyrido[1,2-a]pyrazine derivatives, process for their preparation and pharmaceutical compositions containing them | Les Laboratoires Servier (FR) | 2003-01-15 | — | — | EP | disclosed |