Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 6/20 | 0.49 |
| ▸ | PTAFR | P25105 | 1/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.40 |
| ▸ | HTR1A | P08908 | 3/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.40 |
| ▸ | DRD2 | P14416 | 2/20 | 0.40 |
| ▸ | HTR2A | P28223 | 2/20 | 0.40 |
| ▸ | HTR2C | P28335 | 2/20 | 0.40 |
| ▸ | HTR2B | P41595 | 2/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | SETD7 | Q8WTS6 | 5/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | DRD1 | P21728 | 2/20 | 0.35 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6989716 | 0.88 | HRH1 (0.50) | HRH1PTAFRCHRM2KCNH2HTR2A | |
| SCHEMBL5056412 | 0.88 | HRH1 (0.47) | HRH1PTAFRCHRM2HTR1ACHRM1 | |
| SCHEMBL6988212 | 0.85 | PTAFR (0.47) | HRH1PTAFRCHRM2HTR1ACHRM1 | |
| SCHEMBL5060507 | 0.84 | SETD7 (0.59) | HRH1PTAFRCHRM2HTR1ACHRM1 | |
| SCHEMBL6988099 | 0.82 | HRH1 (0.42) | HRH1PTAFRADRA1AKCNH2ADRA1D | |
| SCHEMBL5060492 | 0.80 | HRH1 (0.47) | HRH1PTAFRCHRM2HTR1ACHRM1 | |
| Fumaric Acid SCHEMBL9243112 | 0.78 | HRH1 (0.48) | HRH1PTAFRCHRM2CHRM1DRD2 | |
| SCHEMBL6996632 | 0.77 | HRH1 (0.52) | HRH1CHRM2HTR1ACHRM1ADRA1A | |
| SCHEMBL6988823 | 0.77 | HRH1 (0.52) | HRH1CHRM2HTR1ACHRM1ADRA1A | |
| SCHEMBL6991414 | 0.76 | HRH1 (0.46) | HRH1CHRM2HTR1ACHRM1ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0588858-B1 | IMIDAZO 2,1-b] 3]BENZAZEPINE DERIVATIVES, COMPOSITIONS AND METHOD OF USE | JANSSEN PHARMACEUTICA NV (BE) | 2003-09-17 | — | — | EP | disclosed |
| US-5468743-A | Imidazo[2,1-b]benzazepine derivatives, compositions and method of use | JANSSEN PHARMACEUTICA N.V. (BE) | 1995-11-21 | — | — | US | disclosed |
| EP-0518435-A1 | Imidazo[2,1-b][3]benzazepine derivatives, compositions and method of use | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-12-16 | — | — | EP | disclosed |