Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 11/20 | 0.42 |
| ▸ | PTAFR | P25105 | 3/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | FNTA | P49354 | 1/20 | 0.33 |
| ▸ | FNTB | P49356 | 1/20 | 0.33 |
| ▸ | FAAH | O00519 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6985481 | 0.82 | HRH1 (0.49) | HRH1PTAFRKCNH2ADRA1DADRA1A | |
| SCHEMBL7144048 | 0.80 | HRH1 (0.34) | HRH1HRH3FAAH | |
| SCHEMBL7139726 | 0.74 | HRH1 (0.38) | HRH1PTAFRFAAHKCNH2ADRA1D | |
| SCHEMBL9234626 | 0.73 | HRH1 (0.40) | HRH1FAAHKCNH2ADRA1DADRA1A | |
| SCHEMBL6991281 | 0.72 | HRH1 (0.43) | HRH1PTAFRFNTAFNTBKCNH2 | |
| SCHEMBL6989716 | 0.71 | HRH1 (0.50) | HRH1PTAFRFNTAFNTBKCNH2 | |
| SCHEMBL5056412 | 0.71 | HRH1 (0.47) | HRH1PTAFRKCNH2ADRA1DADRA1A | |
| Water SCHEMBL5056711 | 0.71 | PTAFR (0.42) | HRH1PTAFRHRH3FNTAFNTB | |
| SCHEMBL6995295 | 0.70 | HRH1 (0.43) | HRH1PTAFRFNTAFNTBKCNH2 | |
| SCHEMBL6988212 | 0.70 | PTAFR (0.47) | HRH1PTAFRFNTAFNTBKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0588858-B1 | IMIDAZO 2,1-b] 3]BENZAZEPINE DERIVATIVES, COMPOSITIONS AND METHOD OF USE | JANSSEN PHARMACEUTICA NV (BE) | 2003-09-17 | — | — | EP | disclosed |
| US-5468743-A | Imidazo[2,1-b]benzazepine derivatives, compositions and method of use | JANSSEN PHARMACEUTICA N.V. (BE) | 1995-11-21 | — | — | US | disclosed |
| EP-0588858-A1 | IMIDAZO 2,1-b] 3]BENZAZEPINE DERIVATIVES, COMPOSITIONS AND METHOD OF USE | JANSSEN PHARMACEUTICA N.V. (BE) | 1994-03-30 | — | — | EP | disclosed |
| WO-1992022551-A1 | IMIDAZO[2,1-b][3]BENZAZEPINE DERIVATIVES, COMPOSITIONS AND METHOD OF USE | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-12-23 | — | — | WO | disclosed |
| EP-0518435-A1 | Imidazo[2,1-b][3]benzazepine derivatives, compositions and method of use | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-12-16 | — | — | EP | disclosed |