Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.65 |
| ▸ | MAOB | P27338 | 1/20 | 0.65 |
| ▸ | HRH2 | P25021 | 16/20 | 0.58 |
| ▸ | HRH1 | P35367 | 16/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6983437 | 0.97 | HRH3 (0.64) | HRH3MAOBHRH2HRH1 | |
| Fumaric Acid SCHEMBL5842139 | 0.94 | HRH3 (0.58) | HRH3MAOBHRH2HRH1 | |
| Fumaric Acid SCHEMBL5842136 | 0.94 | HRH3 (0.58) | HRH3MAOBHRH2HRH1 | |
| Fumaric Acid SCHEMBL5842148 | 0.91 | HRH3 (0.57) | HRH3MAOBHRH2HRH1 | |
| Fumaric Acid SCHEMBL5842158 | 0.91 | HRH3 (0.57) | HRH3MAOBHRH2HRH1 | |
| SCHEMBL6978473 | 0.88 | HRH2 (0.59) | HRH3MAOBHRH2HRH1 | |
| SCHEMBL6986499 | 0.86 | HRH4 (0.67) | HRH3HRH1 | |
| SCHEMBL6987324 | 0.85 | MEN1 (0.47) | HRH3MAOBHRH2HRH1 | |
| SCHEMBL5842805 | 0.82 | HRH3 (0.63) | HRH3HRH2HRH1 | |
| SCHEMBL6980738 | 0.82 | HRH3 (0.49) | HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1275647-B1 | Octahydro-2H-pyrido[1,2-a]pyrazine derivatives, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2003-11-12 | — | — | EP | disclosed |
| EP-1275647-A1 | Octahydro-2H-pyrido[1,2-a]pyrazine derivatives, process for their preparation and pharmaceutical compositions containing them | Les Laboratoires Servier (FR) | 2003-01-15 | — | — | EP | disclosed |