Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.64 |
| ▸ | LTA4H | P09960 | 1/20 | 0.58 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.53 |
| ▸ | BCHE | P06276 | 4/20 | 0.52 |
| ▸ | ACHE | P22303 | 4/20 | 0.52 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.49 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.49 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | HRH1 | P35367 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL5842393 | 0.95 | HRH4 (0.61) | HRH4KDM4EALDH1A1LTA4HHRH3 | |
| Fumaric Acid SCHEMBL5842397 | 0.95 | HRH4 (0.61) | HRH4KDM4EALDH1A1LTA4HHRH3 | |
| SCHEMBL6978473 | 0.87 | HRH2 (0.59) | HRH4KDM4EHRH3L3MBTL1HRH1 | |
| SCHEMBL19236074 | 0.87 | HRH4 (0.50) | HRH4KDM4EALDH1A1LTA4HHRH3 | |
| SCHEMBL6985511 | 0.86 | HRH3 (0.65) | HRH3HRH1 | |
| SCHEMBL6983437 | 0.85 | HRH3 (0.64) | HRH3HRH1 | |
| SCHEMBL6987324 | 0.84 | MEN1 (0.47) | HRH4KDM4EALDH1A1HRH3HRH1 | |
| Fumaric Acid SCHEMBL5842139 | 0.83 | HRH3 (0.58) | HRH3HRH1 | |
| Fumaric Acid SCHEMBL5842136 | 0.83 | HRH3 (0.58) | HRH3HRH1 | |
| Fumaric Acid SCHEMBL5842158 | 0.82 | HRH3 (0.57) | HRH3HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1275647-B1 | Octahydro-2H-pyrido[1,2-a]pyrazine derivatives, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2003-11-12 | — | — | EP | disclosed |
| EP-1275647-A1 | Octahydro-2H-pyrido[1,2-a]pyrazine derivatives, process for their preparation and pharmaceutical compositions containing them | Les Laboratoires Servier (FR) | 2003-01-15 | — | — | EP | disclosed |