Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 3/20 | 0.39 |
| ▸ | DRD2 | P14416 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HPGDS | O60760 | 2/20 | 0.37 |
| ▸ | SMYD2 | Q9NRG4 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL9386205 | 0.95 | DRD3 (0.37) | DRD3DRD2NPC1TSHRMAPK1 | |
| Maleic Acid SCHEMBL9130981 | 0.95 | DRD3 (0.37) | DRD3DRD2NPC1TSHRMAPK1 | |
| Water SCHEMBL7165270 | 0.86 | NPC1 (0.38) | DRD3DRD2NPC1TSHRMAPK1 | |
| Water SCHEMBL6988199 | 0.85 | HRH1 (0.51) | SMYD2HPGDCD274 | |
| Oxalic Acid SCHEMBL7134474 | 0.84 | DRD3 (0.35) | DRD3HPGDSHPGDCD274NAMPT | |
| SCHEMBL9131002 | 0.82 | HRH1 (0.40) | DRD3DRD2NPC1TSHRMAPK1 | |
| SCHEMBL6991964 | 0.80 | HRH1 (0.38) | DRD3DRD2NPC1TSHRMAPK1 | |
| Water SCHEMBL9131901 | 0.78 | HRH1 (0.38) | DRD3DRD2NPC1TSHRMAPK1 | |
| Water SCHEMBL9131896 | 0.78 | HRH1 (0.38) | DRD3DRD2NPC1TSHRMAPK1 | |
| SCHEMBL6991281 | 0.77 | HRH1 (0.43) | DRD3DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0588858-B1 | IMIDAZO 2,1-b] 3]BENZAZEPINE DERIVATIVES, COMPOSITIONS AND METHOD OF USE | JANSSEN PHARMACEUTICA NV (BE) | 2003-09-17 | — | — | EP | disclosed |
| EP-0518435-A1 | Imidazo[2,1-b][3]benzazepine derivatives, compositions and method of use | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-12-16 | — | — | EP | disclosed |