Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 8/20 | 0.38 |
| ▸ | DRD2 | P14416 | 3/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.37 |
| ▸ | HTR2A | P28223 | 2/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.36 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.34 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.34 |
| ▸ | PTAFR | P25105 | 2/20 | 0.34 |
| ▸ | FNTA | P49354 | 1/20 | 0.34 |
| ▸ | FNTB | P49356 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Water SCHEMBL9131901 | 0.88 | HRH1 (0.38) | HRH1DRD2KCNH2HTR2ACHRM2 | |
| Water SCHEMBL9131896 | 0.88 | HRH1 (0.38) | HRH1DRD2KCNH2HTR2ACHRM2 | |
| SCHEMBL9131002 | 0.85 | HRH1 (0.40) | HRH1DRD2KCNH2HTR2ACHRM2 | |
| SCHEMBL6993352 | 0.83 | HRH1 (0.59) | HRH1 | |
| SCHEMBL6991281 | 0.83 | HRH1 (0.43) | HRH1DRD2KCNH2HTR2ACHRM2 | |
| SCHEMBL9130545 | 0.83 | LMNA (0.34) | HRH1DRD2KCNH2HTR2ACHRM2 | |
| SCHEMBL6995295 | 0.81 | HRH1 (0.43) | HRH1DRD2KCNH2HTR2ACHRM2 | |
| SCHEMBL6984394 | 0.80 | HRH1 (0.42) | HRH1DRD2KCNH2HTR2ACHRM2 | |
| SCHEMBL6985767 | 0.80 | DRD3 (0.39) | DRD2DRD3NPC1TSHRMAPK1 | |
| SCHEMBL7088377 | 0.79 | HRH1 (0.35) | HRH1DRD2KCNH2HTR2ACHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0588858-B1 | IMIDAZO 2,1-b] 3]BENZAZEPINE DERIVATIVES, COMPOSITIONS AND METHOD OF USE | JANSSEN PHARMACEUTICA NV (BE) | 2003-09-17 | — | — | EP | disclosed |
| EP-0518435-A1 | Imidazo[2,1-b][3]benzazepine derivatives, compositions and method of use | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-12-16 | — | — | EP | disclosed |