Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 8/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.33 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.33 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MMP1 | P03956 | 1/20 | 0.33 |
| ▸ | FCER2 | P06734 | 1/20 | 0.33 |
| ▸ | MMP3 | P08254 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6979519 | 1.00 | PDE10A (0.34) | PDE10AHDAC4HDAC1HDAC3HDAC7 | |
| SCHEMBL6989991 | 0.94 | HDAC4 (0.34) | PDE10AHDAC4HDAC1HDAC3HDAC7 | |
| SCHEMBL6400676 | 0.83 | PDE10A (0.34) | PDE10AHDAC4HDAC1HDAC3HDAC7 | |
| SCHEMBL6608514 | 0.83 | PDE10A (0.37) | PDE10AHIF1AEPAS1KDM4EKMT2A | |
| SCHEMBL6608790 | 0.83 | PDE10A (0.34) | PDE10AHIF1AEPAS1KDM4EKMT2A | |
| SCHEMBL6078553 | 0.82 | PDE10A (0.35) | PDE10AHIF1AEPAS1KDM4EKMT2A | |
| SCHEMBL6661883 | 0.82 | PDE10A (0.35) | PDE10AHIF1AEPAS1KDM4EKMT2A | |
| SCHEMBL6605020 | 0.82 | PDE10A (0.33) | PDE10AHDAC4HDAC1HDAC3HDAC7 | |
| SCHEMBL6399015 | 0.81 | KDM4E (0.34) | PDE10AHIF1AEPAS1KDM4EKMT2A | |
| SCHEMBL6985491 | 0.81 | HIF1A (0.36) | PDE10AHDAC4HDAC1HDAC3HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1289980-A1 | BICYCLYL OR HETEROBICYCLYLMETHANESULFONYLAMINO-SUBSTITUTED N-HYDROXYFORMAMIDES | SMITHKLINE BEECHAM PLC (GB) | 2003-03-12 | — | — | EP | disclosed |
| WO-2001090100-A1 | BICYCLYL OR HETEROBICYCLYLMETHANESULFONYLAMINO-SUBSTITUTED N-HYDROXYFORMAMIDES | SMITHKLINE BEECHAM P.L.C. (GB) | 2001-11-29 | — | — | WO | disclosed |