Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 10/20 | 0.37 |
| ▸ | MMP9 | P14780 | 2/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | MMP8 | P22894 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | MMP1 | P03956 | 1/20 | 0.32 |
| ▸ | FCER2 | P06734 | 1/20 | 0.32 |
| ▸ | MMP3 | P08254 | 1/20 | 0.32 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
| ▸ | CCR1 | P32246 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6608790 | 0.90 | PDE10A (0.34) | PDE10AMMP9HIF1AEPAS1KDM4E | |
| SCHEMBL6605020 | 0.89 | PDE10A (0.33) | PDE10AMMP9HIF1AEPAS1KDM4E | |
| SCHEMBL6399015 | 0.88 | KDM4E (0.34) | PDE10AMMP9HIF1AEPAS1KDM4E | |
| SCHEMBL6400676 | 0.88 | PDE10A (0.34) | PDE10AMMP9HIF1AEPAS1KDM4E | |
| SCHEMBL6404687 | 0.85 | MMP2 (0.30) | MMP9MMP2MMP8 | |
| SCHEMBL6661883 | 0.83 | PDE10A (0.35) | PDE10AMMP9HIF1AEPAS1KDM4E | |
| SCHEMBL6078553 | 0.83 | PDE10A (0.35) | PDE10AMMP9HIF1AEPAS1KDM4E | |
| SCHEMBL6987834 | 0.83 | HIF1A (0.30) | HIF1AEPAS1 | |
| SCHEMBL6985833 | 0.83 | PDE10A (0.34) | PDE10AMMP9HIF1AEPAS1KDM4E | |
| SCHEMBL6979519 | 0.83 | PDE10A (0.34) | PDE10AMMP9HIF1AEPAS1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1289980-B1 | BICYCLYL OR HETEROBICYCLYLMETHANESULFONYLAMINO-SUBSTITUTED N-HYDROXYFORMAMIDES | SMITHKLINE BEECHAM PLC (GB) | 2004-11-17 | — | — | EP | disclosed |