Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 1/20 | 0.73 |
| ▸ | HTR1D | P28221 | 11/20 | 0.72 |
| ▸ | TRPM8 | Q7Z2W7 | 3/20 | 0.70 |
| ▸ | MAPT | P10636 | 3/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.70 |
| ▸ | LTA4H | P09960 | 2/20 | 0.69 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.69 |
| ▸ | POLB | P06746 | 1/20 | 0.62 |
| ▸ | HTR1A | P08908 | 8/20 | 0.62 |
| ▸ | HTR1B | P28222 | 8/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.62 |
| ▸ | TP53 | P04637 | 1/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.62 |
| ▸ | HTR2A | P28223 | 1/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6982859 | 0.99 | SLC6A4 (0.75) | SLC6A4HTR1DTRPM8MAPTKDM4E | |
| SCHEMBL6987351 | 0.95 | SLC6A4 (0.77) | SLC6A4HTR1DTRPM8MAPTKDM4E | |
| SCHEMBL6988545 | 0.90 | HTR1D (0.78) | SLC6A4HTR1DTRPM8MAPTKDM4E | |
| SCHEMBL2007192 | 0.85 | TRPM8 (0.72) | SLC6A4HTR1DTRPM8MAPTKDM4E | |
| SCHEMBL24183121 | 0.84 | HTR1D (0.69) | SLC6A4HTR1DTRPM8MAPTKDM4E | |
| SCHEMBL20405632 | 0.84 | HTR1D (0.69) | SLC6A4HTR1DTRPM8MAPTKDM4E | |
| SCHEMBL17402414 | 0.83 | HTR1D (0.65) | SLC6A4HTR1DTRPM8MAPTKDM4E | |
| SCHEMBL6388022 | 0.83 | POLB (0.78) | SLC6A4HTR1DTRPM8MAPTKDM4E | |
| SCHEMBL27406721 | 0.83 | TRPM8 (0.77) | SLC6A4HTR1DTRPM8MAPTKDM4E | |
| 5-Benzyloxytryptamine SCHEMBL29785061 | 0.83 | TRPM8 (1.00) | SLC6A4HTR1DTRPM8MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268422-A1 | INDOLES FOR TREATING DISEASES THAT CAN BE TREATED USING THYROID HORMONES | Bayer Aktiengesellschaft (DE) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001070687-A1 | INDOLES FOR TREATING DISEASES THAT CAN BE TREATED USING THYROID HORMONES | BAYER AKTIENGESELLSCHAFT (DE) | 2001-09-27 | — | — | WO | disclosed |