Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Proline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | DPP4 | P27487 | 4/20 | 0.41 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.41 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.41 |
| ▸ | NOS2 | P35228 | 2/20 | 0.41 |
| ▸ | NOS3 | P29474 | 1/20 | 0.41 |
| ▸ | NOS1 | P29475 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | FAP | Q12884 | 1/20 | 0.37 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.37 |
| ▸ | PRCP | P42785 | 1/20 | 0.36 |
| ▸ | SLC6A1 | P30531 | 1/20 | 0.35 |
| ▸ | SLC6A11 | P48066 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Proline SCHEMBL10781489 | 1.00 | MEN1 (0.42) | MEN1BLMKMT2ADPP4DPP8 | |
| Pipecolic Acid SCHEMBL30302226 | 0.94 | MEN1 (0.37) | MEN1BLMKMT2ADPP4DPP8 | |
| Trifluoroacetic Acid SCHEMBL20400915 | 0.90 | MEN1 (0.42) | MEN1BLMKMT2ATSHR | |
| Trifluoroacetic Acid SCHEMBL20400912 | 0.90 | MEN1 (0.42) | MEN1BLMKMT2ATSHR | |
| Proline SCHEMBL2939 | 0.87 | — | — | |
| Proline SCHEMBL10141185 | 0.87 | — | — | |
| Proline SCHEMBL13248912 | 0.87 | — | — | |
| D-Proline SCHEMBL21462052 | 0.87 | BLM (0.52) | MEN1BLMKMT2ADPP4DPP8 | |
| Proline SCHEMBL462226 | 0.87 | BLM (0.52) | MEN1BLMKMT2ADPP4DPP8 | |
| Proline SCHEMBL10141181 | 0.87 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109678859-B | Dihydropyrimidine compound and application thereof in medicine | 广东东阳光药业有限公司 | 2020-12-29 | — | — | CN | disclosed |
| EP-3697792-A1 | DIHYDROPYRIMIDINE COMPOUNDS AND USES THEREOF IN MEDICINE | Sunshine Lake Pharma Co., Ltd. (CN) | 2020-08-26 | — | — | EP | disclosed |
| CN-110713484-A | Xanthene fluorescent compound easy to combine and preparation and application thereof | 罗宇峰 | 2020-01-21 | — | — | CN | disclosed |
| WO-2019076310-A1 | DIHYDROPYRIMIDINE COMPOUNDS AND USES THEREOF IN MEDICINE | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2019-04-25 | — | — | WO | disclosed |
| CN-106715418-A | Therapeutic compounds and methods of use thereof | 基因泰克公司 | 2017-05-24 | — | — | CN | disclosed |
| CN-102159207-A | Substituted pyrrolidine-2-carboxamides | HOFFMANN LA ROCHE | 2011-08-17 | — | — | CN | disclosed |
| EP-1358154-A2 | PYRROLIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF NEURAMINIDASES | Abbott Laboratories (US) | 2003-11-05 | — | — | EP | disclosed |
| EP-1315698-A1 | PYRROLIDINES AS INHIBITORS OF NEURAMINIDASES | ABBOTT LABORATORIES (US) | 2003-06-04 | — | — | EP | disclosed |
| WO-2001028996-A2 | PYRROLIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF NEURAMINIDASES | ABBOTT LABORATORIES (US) | 2001-04-26 | — | — | WO | disclosed |
| WO-1999054299-A1 | PYRROLIDINES AS INHIBITORS OF NEURAMINIDASES | ABBOTT LABORATORIES (US) | 1999-10-28 | — | — | WO | disclosed |
| CN-1217327-A | D-proline derivative | HOFFMANN LA ROCHE (CH) | 1999-05-26 | — | — | CN | disclosed |
| EP-0084941-B1 | AMIDE DERIVATIVES | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1987-03-11 | — | — | EP | disclosed |