Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.45 |
| ▸ | AAK1 | Q2M2I8 | 6/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ALPL | P05186 | 1/20 | 0.38 |
| ▸ | ALPI | P09923 | 1/20 | 0.38 |
| ▸ | ALPG | P10696 | 1/20 | 0.38 |
| ▸ | CBFB | Q13951 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4107335 | 0.82 | HSD17B10 (0.61) | SCN10AAAK1KDM4EHSD17B10LMNA | |
| SCHEMBL24075322 | 0.79 | AAK1 (0.48) | SCN10AAAK1KDM4EHSD17B10LMNA | |
| SCHEMBL5118214 | 0.79 | AAK1 (0.48) | SCN10AAAK1KDM4EHSD17B10LMNA | |
| SCHEMBL9263421 | 0.79 | KDM4E (0.71) | SCN10AAAK1KDM4EHSD17B10LMNA | |
| SCHEMBL4777406 | 0.78 | HTT (0.40) | AAK1KDM4EHSD17B10LMNAALDH1A1 | |
| SCHEMBL26427165 | 0.75 | CYP1A2 (0.67) | SCN10AAAK1KDM4EHSD17B10LMNA | |
| SCHEMBL12727236 | 0.75 | CYP1A2 (0.50) | SCN10AAAK1KDM4EHSD17B10LMNA | |
| SCHEMBL6987043 | 0.74 | SCN10A (0.35) | SCN10AAAK1ALPLALPIALPG | |
| SCHEMBL10299140 | 0.74 | KDM4E (0.51) | SCN10AAAK1KDM4EHSD17B10LMNA | |
| SCHEMBL23676476 | 0.74 | SCN10A (0.43) | SCN10AAAK1KDM4EHSD17B10LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100324029-A1 | THERAPEUTIC AGENTS | MERCK SHARP & DOHME CORP. | 2010-12-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100324029-A1 | THERAPEUTIC AGENTS | PSEN2, PSEN1, BACE2 | SCN10A 3312/4885AAK1 2672/4885KDM4E 3970/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.