Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.39 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11512531 | 0.90 | ALDH1A1 (0.53) | ALDH1A1TDP1TSHRGPR35MAPT | |
| SCHEMBL29057016 | 0.84 | AKR1B1 (0.50) | ALDH1A1TDP1GPR35MAPTKMT2A | |
| SCHEMBL9944129 | 0.84 | ALDH1A1 (0.43) | ALDH1A1TDP1TSHRGPR35MAPT | |
| SCHEMBL2059346 | 0.82 | MAPT (0.49) | ALDH1A1GPR35MAPTKMT2ACYP3A4 | |
| SCHEMBL5233148 | 0.81 | MAPT (0.49) | ALDH1A1TSHRMAPTKMT2AMEN1 | |
| SCHEMBL304765 | 0.81 | TDP1 (0.49) | ALDH1A1TDP1TSHRGPR35MAPT | |
| SCHEMBL10872347 | 0.80 | ALDH1A1 (0.44) | ALDH1A1TDP1TSHRGPR35MAPT | |
| SCHEMBL7866986 | 0.80 | ALDH1A1 (0.46) | ALDH1A1TDP1TSHRGPR35MAPT | |
| SCHEMBL3796689 | 0.79 | ALDH1A1 (0.53) | ALDH1A1TDP1TSHRGPR35MAPT | |
| SCHEMBL27641657 | 0.79 | HTT (0.52) | ALDH1A1TDP1TSHRGPR35MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-59070649-A | — | — | None | — | — | JP | disclosed |
| US-7863306-B2 | Broadspectrum 2-amino-benzoxazole sulfonamide HIV protease inhibitors | TIBOTEC PHARMACEUTICALS LTD (IE) | 2011-01-04 | — | — | US | disclosed |
| US-20100029632-A1 | BROADSPECTRUM 2-AMINO-BENZOXAZOLE SULFONAMIDE HIV PROTEASE INHIBITORS | SURLERAUX DOMINIQUE LOUIS NEST | 2010-02-04 | — | — | US | disclosed |
| US-7622490-B2 | especially for multi-drug resistant strains | TIBOTEC PHARMACEUTICALS, LTD. (IE) | 2009-11-24 | — | — | US | disclosed |
| EP-0995743-B1 | Derivatives of dihydro- and tetrahydrochinoline as a medicinal antioxydans | SERVIER LAB (FR) | 2003-04-02 | — | — | EP | disclosed |
| US-6350759-B1 | ANTIOXIDATIVE AGENTS FOR OXIDATION STRESS, ESPECIALLY AT THE CEREBRAL LEVEL; | ADIR ET COMPAGNIE (FR) | 2002-02-26 | — | — | US | disclosed |
| EP-0995743-A1 | Derivatives of dihydro- and tetrahydrochinoline as a medicinal antioxydans | ADIR ET COMPAGNIE (FR) | 2000-04-26 | — | — | EP | disclosed |
| US-5516788-A | TREATMENT OF ATHEROSCLEROSIS; ANTIISCHEMIC, ANTICARCINOGENIC AGENTS; ANTICOAGULANTS | UNIVERSITY OF BATH (GB) | 1996-05-14 | — | — | US | disclosed |
| CN-1061962-A | INDENOINDOLE COMPOUNDS | UNIV BATH (GB) | 1992-06-17 | — | — | CN | disclosed |
| WO-1992006956-A1 | INDENOINDOLE COMPOUNDS | UNIVERSITY OF BATH (GB) | 1992-04-30 | — | — | WO | disclosed |
| EP-0481708-A1 | Indenoindole compounds | UNIVERSITY OF BATH (GB) | 1992-04-22 | — | — | EP | disclosed |
| EP-0106326-A1 | 1-Amino or nitro-3,5-disubstituted-4-ethoxybenzenes and their production | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1984-04-25 | — | — | EP | disclosed |
| JP-S5970649-A | 4-ETHOXYNITROBENZENE DERIVATIVE AND ITS PREPARATION | SUMITOMO CHEM CO LTD | 1984-04-21 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029632-A1 | BROADSPECTRUM 2-AMINO-BENZOXAZOLE SULFONAMIDE HIV PROTEASE INHIBITORS | CYP2S1, CYP2C8, CYP2A7 | ALDH1A1 1387/4885TDP1 3884/4885TSHR 4295/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.