Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 3/20 | 0.31 |
| ▸ | MMP9 | P14780 | 2/20 | 0.31 |
| ▸ | ANPEP | P15144 | 2/20 | 0.31 |
| ▸ | LTA4H | P09960 | 1/20 | 0.31 |
| ▸ | LAP3 | P28838 | 1/20 | 0.31 |
| ▸ | NPEPPS | P55786 | 1/20 | 0.31 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.31 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.31 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.31 |
| ▸ | MMP3 | P08254 | 2/20 | 0.30 |
| ▸ | MMP1 | P03956 | 1/20 | 0.30 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6988674 | 0.93 | MMP2 (0.31) | MMP2MMP9ANPEPLTA4HLAP3 | |
| SCHEMBL6982294 | 0.91 | MMP2 (0.30) | MMP2MMP9ANPEPLTA4HLAP3 | |
| SCHEMBL6987274 | 0.91 | MMP2 (0.31) | MMP2MMP9ANPEPLTA4HLAP3 | |
| SCHEMBL6987085 | 0.91 | MMP2 (0.32) | MMP2MMP9ANPEPLTA4HLAP3 | |
| SCHEMBL6986897 | 0.90 | MEN1 (0.32) | MMP2MMP9ANPEPLTA4HLAP3 | |
| SCHEMBL6987112 | 0.90 | MMP2 (0.32) | MMP2MMP9ANPEPLTA4HLAP3 | |
| SCHEMBL6979980 | 0.90 | — | — | |
| SCHEMBL6986331 | 0.89 | — | — | |
| SCHEMBL6982341 | 0.89 | CTSC (0.30) | — | |
| SCHEMBL6946851 | 0.88 | MMP2 (0.33) | MMP2MMP9ANPEPLTA4HLAP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1089964-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-10-29 | — | — | EP | disclosed |
| EP-1089964-A1 | HYDRAZINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2001-04-11 | — | — | EP | disclosed |
| WO-2000000465-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-01-06 | — | — | WO | disclosed |