Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR1A | P37288 | 13/20 | 0.80 |
| ▸ | AVPR1B | P47901 | 7/20 | 0.80 |
| ▸ | AVPR2 | P30518 | 6/20 | 0.66 |
| ▸ | OXTR | P30559 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | GLA | P06280 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6990006 | 0.93 | AVPR1A (0.79) | AVPR1AAVPR1BAVPR2OXTR | |
| SCHEMBL6989046 | 0.89 | AVPR1A (1.00) | AVPR1AAVPR1BAVPR2OXTR | |
| SCHEMBL6991357 | 0.86 | AVPR1A (0.68) | AVPR1AAVPR1BAVPR2OXTRKDM4E | |
| SCHEMBL8798138 | 0.85 | AVPR1A (0.77) | AVPR1AAVPR1BAVPR2OXTR | |
| SCHEMBL6989132 | 0.85 | AVPR1A (0.85) | AVPR1AAVPR1BAVPR2OXTR | |
| SCHEMBL6988098 | 0.85 | AVPR1A (0.74) | AVPR1AAVPR1BAVPR2OXTRKMT2A | |
| SCHEMBL6988983 | 0.83 | AVPR1A (0.79) | AVPR1AAVPR1BAVPR2KMT2A | |
| SCHEMBL6993669 | 0.81 | AVPR1A (0.79) | AVPR1AAVPR1BAVPR2KMT2A | |
| SCHEMBL6988528 | 0.81 | AVPR1A (1.00) | AVPR1AAVPR1BAVPR2OXTR | |
| SCHEMBL7365160 | 0.81 | AVPR1A (0.68) | AVPR1AAVPR1BAVPR2OXTRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0811008-B1 | BICYCLIC BENZAZEPINE DERIVATIVES AS VASOPRESSIN ANTAGONISTS | WYETH CORP (US) | 2003-10-01 | — | — | EP | claimed |
| US-5696112-A | TREATMENT OF CONGESTIVE HEART FAILURE, CORONARY VASOCONSTRICTION | AMERICAN CYANAMID COMPANY (US) | 1997-12-09 | — | — | US | claimed |
| US-5654297-A | CONGESTIVE HEART FAILURE, CARDIOVASCULAR DISORDERS | AMERICAN CYANAMID COMPANY (US) | 1997-08-05 | — | — | US | claimed |
| WO-1996022294-A1 | BICYCLIC BENZAZEPINE DERIVATIVES AS VASOPRESSIN ANTAGONISTS | AMERICAN CYANAMID COMPANY (US) | 1996-07-25 | — | — | WO | claimed |
| US-5696112-A | TREATMENT OF CONGESTIVE HEART FAILURE, CORONARY VASOCONSTRICTION | AMERICAN CYANAMID COMPANY (US) | 1997-12-09 | — | — | US | disclosed |
| US-5654297-A | CONGESTIVE HEART FAILURE, CARDIOVASCULAR DISORDERS | AMERICAN CYANAMID COMPANY (US) | 1997-08-05 | — | — | US | disclosed |